Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Insensitive Nuclei Enhanced by Polarization Transfer (INEPT)01:15

Insensitive Nuclei Enhanced by Polarization Transfer (INEPT)

966
Insensitive Nuclei Enhanced by Polarization Transfer (INEPT) is an advanced Nuclear Magnetic Resonance (NMR) technique specifically designed to detect and enhance the signals of low-abundance nuclei, such as carbon-13 and nitrogen-15, in small molecules. The fundamental principle behind INEPT is the transfer of polarization from a more abundant and highly polarizable nucleus, typically hydrogen-1, to the low-abundance nucleus of interest. This process effectively boosts the NMR signal of the...
966
Directionality of Nuclear Transport01:42

Directionality of Nuclear Transport

4.5K
Ras-related nuclear protein or Ran is a small G protein that cycles between its GTP and GDP bound states. Ran specific regulators, a Ran GTPase Activating Protein or RanGAP present in the cytosol and a Ran guanine nucleotide exchange factor or RanGEF present inside the nucleus regulate GTP/GDP exchange. A high concentration of GTP inside the cells, in addition to this asymmetric distribution of  Ran-specific regulators, leads to a higher RanGTP concentration inside the nucleus. This...
4.5K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Design, synthesis, and activity evaluation of novel arylpyrrolidinones NMT antifungal inhibitors.

Bioorganic chemistry·2026
Same author

Deep learning for predicting pituitary neuroendocrine tumour lineage and high-risk subtypes from histology.

NPJ precision oncology·2026
Same author

Construction and Activity Evaluation of Biphenyl Hydroxamic Acid Dual-Target Antibacterial Inhibitor and Nanocarrier.

ACS infectious diseases·2026
Same author

Innate immune sensing via the cGAS-STING pathway restricts extrachromosomal DNA-driven tumorigenesis.

bioRxiv : the preprint server for biology·2026
Same author

Transformer-based multimodal fusion framework for predicting postoperative cognitive improvement in glioma: integrating radiomics and pathomics.

International journal of surgery (London, England)·2025
Same author

From Pharmacophore Models to Lead Compounds: Construction and Activity Evaluation of Novel Indoleamine 2,3-Dioxygenase-1 Inhibitors.

Chemical biology & drug design·2025

相关实验视频

Updated: Jan 8, 2026

Using Computer Vision Libraries to Streamline Nuclei Quantification
06:25

Using Computer Vision Libraries to Streamline Nuclei Quantification

Published on: June 6, 2025

602

VGFA:用于域自适应核检测的变化-坚固的图形级特征对齐.

Kai Fan, Zhi Wang, Aiqiu Wu

    IEEE transactions on medical imaging
    |December 18, 2025
    PubMed
    概括
    此摘要是机器生成的。

    这项研究引入了一个新的框架,用于在病理图像中检测强大的核,解决域差异和域内变异. 该方法通过改善核检测模型的无监督域适应来提高疾病诊断的准确性.

    更多相关视频

    Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation
    07:15

    Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation

    Published on: January 16, 2019

    11.3K
    Author Spotlight: Comprehensive Epigenetic Analysis for Investigating Human Cellular Plasticity and Environmental Adaptation Using Immunofluorescence Assays
    06:33

    Author Spotlight: Comprehensive Epigenetic Analysis for Investigating Human Cellular Plasticity and Environmental Adaptation Using Immunofluorescence Assays

    Published on: June 28, 2024

    866

    相关实验视频

    Last Updated: Jan 8, 2026

    Using Computer Vision Libraries to Streamline Nuclei Quantification
    06:25

    Using Computer Vision Libraries to Streamline Nuclei Quantification

    Published on: June 6, 2025

    602
    Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation
    07:15

    Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation

    Published on: January 16, 2019

    11.3K
    Author Spotlight: Comprehensive Epigenetic Analysis for Investigating Human Cellular Plasticity and Environmental Adaptation Using Immunofluorescence Assays
    06:33

    Author Spotlight: Comprehensive Epigenetic Analysis for Investigating Human Cellular Plasticity and Environmental Adaptation Using Immunofluorescence Assays

    Published on: June 28, 2024

    866

    科学领域:

    • 数字病理学数字病理学
    • 计算生物学 计算生物学
    • 医学图像分析 医学图像分析

    背景情况:

    • 精确的核检测对于病理图像分析在疾病诊断和治疗中至关重要.
    • 病理图像中的域差异和域内变异 (IDV) 显著降低了检测模型的性能.
    • 现有的域适应方法经常忽视IDV在细胞和图像尺度上的影响.

    研究的目的:

    • 为无监督域适应性核检测提出一种新型变异-强大的图形级特征对齐 (VGFA) 框架.
    • 为了应对病理图像中显著的域差异和域内变异带来的挑战.
    • 提高在各种病理数据集中核检测模型的性能和稳定性.

    主要方法:

    • 开发了一个变化强大的图形级特征对齐 (VGFA) 框架.
    • 整合了基于先前的核图形修剪方案,以消除不可靠的节点.
    • 设计了一个局部-全球核编码网络,用于整体核图形表示学习.
    • 采用了对图像尺度IDV有弹性的核图形差异损失,用于跨域特征对齐.

    主要成果:

    • VGFA框架在无监督域自适应核检测方面展示了最先进的性能.
    • 与现有的特征对齐方法相比,在各种适应情景中取得了优异的结果.
    • 在细胞和图像尺度上有效地减轻域内变化的有害影响.

    结论:

    • 拟议的VGFA框架在存在显著的域差异和域内变异的情况下,为核检测提供了一个强大的解决方案.
    • VGFA提高了数字病理学中核检测模型的可靠性和准确性.
    • 这一进步通过改进的图像分析,有助于更精确的疾病诊断和治疗计划.