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Spatiotemporal Control of Protein Activity through Optogenetic Allosteric Regulation
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合规的景观适应使Src家族激酶的过程化成为可能

Yixin Cui1, Rustam Ali1, Mary Clay1

  • 1Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.

Science (New York, N.Y.)
|December 18, 2025
PubMed
概括

通过过渡的中间状态,Src家族激酶实现过程性酸化. 在细胞信号传输中,这种构造状态对于有效的催化周转和多位基板改造至关重要.

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