多种癌症早期检测 癌症幸存者的血液检测表现 来自PATHFINDER研究
Catherine R Marinac1, Elizabeth K O'Donnell1, Christina A Clarke2
1Dana-Farber Cancer Institute, Boston, MA.
JCO precision oncology
|December 18, 2025
概括
针对多种癌症的早期检测 (MCED) 的血液检测显示出对癌症幸存者的监测有前途. 这项研究发现,MCED测试可以帮助在幸存者中检测新的癌症,解决对长期监测策略的关键需求.
科学领域:
- 在瘤学瘤学.
- 生物标志物 生物标志物
- 癌症的生存率 癌症的生存率
背景情况:
- 癌症幸存者面临复发和新的原发性癌症的风险增加.
- 对幸存者的长期监测策略往往缺乏全面的指导.
- 早期发现二次恶性瘤对于改善患者的治疗结果至关重要.
研究的目的:
- 为了评估基于血液的多种癌症早期检测 (MCED) 测试的性能.
- 评估MCED测试在癌症幸存者队列中的有用性.
- 为解决有效的长期癌症监测的未满足需求.
主要方法:
- 一项前性研究 (PATHFINDER) 涉及1,609名目前没有癌症怀疑的成年人.
- 评估了参与者的基于血液的MCED测试的表现.
- 包括癌症幸存者与各种先前的癌症类型和诊断持续时间.
主要成果:
- 在1.2% (20/1,609) 的参与者中检测到癌症信号.
- 确定了10种新的癌症诊断:5种是第二次原发性癌症,5种是复发性癌症 (乳腺癌).
- 在最初诊断几年后诊断出第二次原发性和复发性; MCED测试的表现在各组之间是一致的.
结论:
- 基于血液的MCED测试显示了长期癌症幸存者监测的潜力.
- MCED测试可能有助于识别幸存者的新癌症,解决显著的临床需求.
- 进一步的研究可以验证MCED测试在癌症幸存者护理中常规使用.
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