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在乳腺癌患者中,散步剂量与较低的癌症相关疲劳有关

Lindsey J Mattick¹, Chin-Shang Li¹, Po-Ju Lin¹

¹Division of Supportive Care in Cancer, Department of Surgery, School of Medicine and Dentistry, University of Rochester, Rochester, NY, 14624 USA.

Journal of the National Cancer Institute

|December 18, 2025

概括

这项研究发现,较高的步行量显著降低了乳腺癌患者的癌症相关疲劳 (CRF). 每周至少88-172分钟的低强度或43-83分钟的中等强度步行可以有效地缓解CRF.

科学领域:

在瘤学瘤学.
运动生理学运动生理学
癌症的生存率癌症的生存率

背景情况:

癌症相关疲劳 (CRF) 是癌症治疗的常见和严重的副作用.
目前用于通过运动管理CRF的临床指南缺乏关于走路的具体建议.
这项研究旨在确定最佳的步行剂量,以减轻乳腺癌患者的CRF.

研究的目的:

确定步行运动的具体体积,强度和持续时间,有效减少与癌症相关的疲劳 (CRF).
为癌症患者管理CRF的运动处方提供基于证据的建议.

主要方法:

一项全国范围的前性队列研究,涉及577名患有I-IIIC阶段乳腺癌的患者.
在多个时间点评估行走量 (MET-小时/周) 和CRF (多维疲劳症状清单):化疗前,化疗后1个月,化疗后6个月.
使用接收机运行特征曲线和线性混合模型进行统计分析,以确定最佳步行切断点及其与CRF减少的关联.

主要成果:

较高的步行量显著与一般,情绪和身体CRF减少以及化疗后活力增加有关.
参与者每周步行≥4.3MET小时 (相当于每周88-172分钟的低强度步行或每周43-83分钟的中等强度步行) 在化疗后显著降低了CRF.
这些好处在化疗前,期间和后期间都被观察到.

结论:

增加步行量与乳腺癌患者的癌症相关疲劳 (CRF) 的降低有关.
在化疗后,每周至少进行88-172分钟的低强度步行或43-83分钟的中等强度步行可以有效地减轻CRF.
这些发现支持将特定的步行处方纳入癌症护理指南,以管理CRF.

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