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COVID-19大流行对早期生活肠道微生物群的影响

Lin Zhang^1,2, Wenye Xu^1,2, Henry Y H Meng³

¹Microbiota I-Center (MagIC), The Chinese University of Hong Kong, Hong Kong SAR, China.

|December 18, 2025

概括

由于增加了卫生条件,COVID-19封锁改变了婴儿肠道微生物组的发展. 这项研究观察了大流行期间出生的婴儿微生物多样性和抗生素耐药性基因的变化.

科学领域:

微生物组研究的研究.
儿科卫生健康儿科卫生健康
传染病流行病学传染病流行病学

背景情况:

提高卫生和卫生条件与亚托皮性疾病有关,可能是通过肠道微生物群.
生命的第一年对微生物群的发展至关重要,受到环境暴露的影响.

研究的目的:

调查COVID-19封锁措施对婴儿早期肠道微生物组成熟的影响.
评估疫情期间提高卫生标准如何影响婴儿肠道微生物组的发展.

主要方法:

在中国大湾区的两个大型母婴队列 (COVID-19前和期间) 的比较.
对肠道微生物群多样性,组成和功能基因含量 (抵抗基因) 的分析.

主要成果:

在COVID-19期间,在婴儿身上观察到肠道微生物群多样性,组成和发育轨迹的显著变化.
在COVID期间的队列中,抗微生物和抗生素耐药性基因的丰度下降.
特定的细菌物种显示出抗生素耐药性基因配置的改变: * Staphylococcus epidermidis * 具有较少的耐药性基因,而 * Klebsiella pneumoniae * 具有更多的基诺耐药性基因.

结论:

COVID-19 卫生措施显著影响了早期肠道微生物组的成熟.
研究结果强调,在评估卫生干预措施时,需要考虑微生物组的改变.
需要进一步的研究,以了解肠道微生物组在流行病相关的卫生变化后疾病发展中的作用.

关键词:

在 COVID-19 疫情中,早期的生活早期生活环境和公共卫生公共卫生我们的肠道微生物组.卫生假设卫生假设流行病是一种流行病.

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