通过ACOX3的多组组特征分析,揭示了潜在的泛癌临床生物标志物
Wan-Li Wang1, Qiao Xiong2, Bo Ma1
1State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, China.
Computational biology and chemistry
|December 18, 2025
概括
乙-甲酸氧化酶3 (ACOX3) 显示为一种泛癌生物标志物具有前途. 它的表达影响患者的预后,并与瘤免疫相互作用,表明治疗潜力.
科学领域:
- 在瘤学瘤学.
- 生物标志物发现发现
- 癌症基因组学 癌症基因组学
背景情况:
- 乙基-CoA氧化酶3 (ACOX3) 涉及到各种细胞过程.
- 它作为胰腺癌生物标志物的作用在很大程度上仍然未被描述.
研究的目的:
- 为了全面描述ACOX3作为一种新的胰腺癌生物标志物.
- 评估其表达异质性,临床相关性,瘤免疫相互作用和多种癌症类型的治疗潜力.
主要方法:
- 对ACOX3表达的多个omics分析.
- 使用考克斯回归,卡普兰-梅尔生存率和ROC分析进行预后和诊断意义评估.
- 免疫细胞透,检查点和免疫调节活性评估.
- 通过分子对接和动态模拟来预测药物敏感性.
- 在头部和部状细胞癌 (HNSCC) 细胞系中的实验验验证.
主要成果:
- 在不同癌症类型中,ACOX3的表达有显著的差异,在KICH,PRAD,THCA上调,在COAD,HNSCC,KIRP,LIHC,STAD下调.
- 高ACOX3表达与HNSCC的良好预后相关,但在LGG和UVM中结果不佳.
- 在HNSCC中,ACOX3表达与CD4+ T,CD8+ T和NK细胞正相关,恶性区域的丰富.
- 确定AZD6482和TGX-221是高亲和度的ACOX3抑制剂,AZD6482显示稳定结合.
- 过度表达ACOX3抑制了HNSCC细胞的增殖,入侵和迁移.
结论:
- ACOX3作为一个双重的诊断和预后生物标志物,具有广泛的泛癌相关性.
- 鉴定了ACOX3.3的明显的免疫相关物和治疗潜力.
- 需要对针对ACOX3的治疗方法进行进一步的研究.
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