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暴露于电子烟烟雾的老鼠血中的咖啡因迅速出现,使用经过验证的LC-MS/MS方法进行分析

Keisuke Muranaka¹, Junpei Mutoh¹, Makoto Takada²

¹Faculty of Pharmaceutical Sciences, Sanyo-Onoda City University, 1-1-1 Daigakudori, Sanyo-Onoda, Yamaguchi 756-0884, Japan.

Journal of pharmaceutical and biomedical analysis

|December 18, 2025

概括

通过电子烟吸入咖啡因 (Caf) 会导致老鼠的快速吸收,峰值度比口服摄入更快. 这项研究揭示了电子烟咖啡因输送的独特药理动力学特性.

科学领域:

药理学和毒理学药理学和毒理学
分析化学分析化学
药物输送系统药物输送系统

背景情况:

有提供咖啡因 (Caf) 的电子烟 (e-cigarettes),但它们的药理动力学 (PK) 特性基本上是未知的.
通过吸入电子烟来了解Caf吸收对于评估潜在的健康影响至关重要.

研究的目的:

为了比较口服后大鼠血中Caf及其代谢物的PK参数与电子烟烟雾暴露.
使用经过验证的LC-MS/MS方法量化Caf及其代谢物.

主要方法:

一种经过验证的液体染色学-并联质谱法 (LC-MS/MS) 方法被用于量化Caf及其代谢物 (素,西奥菲林等) 在大鼠血中.
鼠被暴露在含有Caf的电子烟烟雾中1分钟和3分钟,收集血长达90分钟.
分析了PK参数,并比较了电子烟暴露和口服Caf的使用.

主要成果:

通过LC-MS/MS方法,在大鼠血中成功量化了Caf,偏素 (PX) 和神素 (TP).
电子烟暴露1分钟和3分钟后的最大Caf度与低剂量口服剂量相比较.
与口服相比,电子烟暴露导致明显更快的峰值度时间和更高的吸收率常数 (P <0.05).

结论:

这项研究首次证明,在暴露于电子烟烟雾后,大鼠血中咖啡因迅速出现.
与口服摄入相比,电子烟吸入提供了一种独特而快速的咖啡因输送途径.
需要进一步的研究来探索这些快速PK特性带来的影响.

关键词:

咖啡因咖啡因是一种咖啡因.电子烟是一种电子烟.这是LC-MS/MS.药物动力学评估药物动力学评估

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