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对梯度和等级支架的回顾:通过电和挤出技术进行机械设计和制造
Benyamin Sarikhani1, Rana Imani2, Mohammad Reza Razfar1
1Department of Mechanical Engineering, Amirkabir University of Technology, Tehran, Iran.
Biomedical materials (Bristol, England)
|December 18, 2025
概括
本综述探讨了组织工程的梯度和等级支架,重点关注诸如电和挤出等制造方法. 这些仿生支架旨在复制自然组织结构,用于再生医学应用.
科学领域:
- 生物材料科学 生物材料科学
- 组织工程是组织工程.
- 再生医学是一种再生医学.
背景情况:
- 模仿细胞外基质的生物模拟性支架对于组织工程至关重要.
- 梯度和等级支架为组织再生提供了先进的结构复杂性.
研究的目的:
- 在组织工程中提供渐变和等级支架的全面审查.
- 突出制造技术,应用,挑战和该领域的未来方向.
主要方法:
- 基于电,基于挤出和混合制造技术的审查.
- 分析设计原则,机械考虑和材料整合.
- 在各种组织类型中探索支架应用.
主要成果:
- 梯度和层次的支架可以有效地模仿自然组织结构.
- 诸如电和挤出等制造方法可以精确控制脚手架架构.
- 在将这些支架应用于骨,软骨,肌,带和血管组织工程方面取得了重大进展.
结论:
- 先进的仿生支架具有巨大的潜力,可以彻底改变组织工程和再生医学.
- 需要进一步的研究来克服制造的局限性,可扩展性问题,并整合智能材料.
- 新兴趋势指向更复杂和响应的脚手架设计,以提高治疗效果.
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