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通过个性化的FLASH优化功能来减轻FLASH模型不确定性的影响,以优化肺部IMPT的传递模式

Manon C van Zon^1,2, Sebastiaan Breedveld¹, Mischa S Hoogeman^1,2

¹Department of Radiotherapy, Erasmus MC Cancer Institute, University Medical Center Rotterdam, Rotterdam, The Netherlands.

Physics in medicine and biology

|December 18, 2025

概括

本研究引入了剂量依赖于剂量率的输送模式优化,以增强放射治疗中的FLASH效应,改善在更广泛的剂量率范围内的剂量分配.

科学领域:

辐射疗法辐射疗法
医学物理医学物理
辐射瘤学辐射瘤学

背景情况:

放射治疗中的FLASH效应传统上是在高剂量速率 (DRs) ≥40 Gy/s时触发的.
最近的证据表明,FLASH效应在不同患者样本中存在一个sigmoid关系,而不是一个二进制值.
目前的FLASH模型不考虑这种变异性,可能会限制治疗疗效.

研究的目的:

开发和评估一种优化FLASH加权剂量 (FWD) 分布的方法.
为了在更广泛的剂量速率范围内最大限度地提高FLASH效应,使用剂量依赖的FLASH递送模式优化 (DPO).
为了保持FLASH效应在40 Gy/s的既定值,同时探索较低的DRs.

主要方法:

优化和评估了1397个使用DPO的FWD发行版的FLASH优化函数.
在1060 Gy/s的剂量速率范围内评估了FWD分布.
将优化的FWD分布与优化的FWD分布进行比较,假设二进制值为40 Gy/s.

主要成果:

FLASH优化功能显著改善了FWD分布.
最佳的FLASH优化功能是针对患者和光束的.
对于FLASH优化函数的类解决方案也产生了整体FWD分布的改进.

结论:

剂量依赖的FLASH优化功能可以大大改善FWD分布.
在更广泛的剂量速率范围内利用FLASH效应是可行的和有益的.
个性化优化策略是最大化FLASH放射治疗益处的关键.

关键词:

一个闪光灯.质子疗法是一种质子疗法.坚固性坚固性坚固性治疗计划治疗计划

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