在有COVID-19感染史的成年人中,REM - 主要阻塞性睡眠呼吸暂停:一项病例对照研究
1Dept of Pulmonary Medicine, Basaksehir Cam Ve Sakura City Hospital, Istanbul, Turkiye.
Sleep medicine
|December 18, 2025
概括
以前患有COVID-19感染的个体患有REM主导阻塞性睡眠呼吸暂停 (OSA) 的患病率较高,这种疾病与疲劳和长期COVID症状有关. 识别这种特定的OSA表型对于患者管理至关重要.
科学领域:
- 睡眠医学 睡眠医学
- 传染性疾病 传染性疾病
- 肺部病理学 肺部病理学
背景情况:
- 阻塞性睡眠呼吸暂停 (OSA) 已经被事地与COVID-19联系在一起.
- 了解COVID-19后成年人中特定的OSA表型至关重要.
研究的目的:
- 调查COVID-19病史的成年人中OSA的发生和特征.
- 探索COVID-19感染,OSA表型和长期COVID症状,特别是疲劳之间的关联.
主要方法:
- 一个匹配的病例对照研究,涉及152名以前患有COVID-19的个人和152名对照人群,年龄,性别和BMI相匹配.
- 基于呼吸暂停-呼吸暂停指数 (AHI) ≥15/h的OSA诊断;REM占主导地位的OSA定义为AHI ≥15/h和REM-AHI/非REM-AHI ≥2.2.
- 疲劳,作为长期COVID的替代品,使用自我报告的频率进行评估.
主要成果:
- 在COVID-19组中,OSA患病率较低 (50.0%) 与对照组 (77.6%) 相比.
- 在COVID-19病例中,REM占主导地位的OSA明显比对照组 (17.8%) 更常见 (47.4%).
- 之前的COVID-19感染与REM占主导地位的OSA (OR 3.14) 有很强的相关性. 疲劳与REM占主导地位的OSA (OR 2.18) 和女性性别 (OR 2.02) 有关.
结论:
- 在有COVID-19病史的人群中,REM占主导地位的OSA非常普遍.
- 这种特定的OSA表型与疲劳显著相关,疲劳是长期COVID的关键症状.
- 对于经COVID-19患者经历疲劳,建议对REM占主导地位的OSA进行临床评估.
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