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Insulin is released by beta cells of the pancreas when blood glucose levels are high. It facilitates glucose absorption and utilization in insulin-dependent cells with insulin receptors on their plasma membranes. Insulin promotes glucose uptake by increasing the number of glucose transport proteins in the cell membrane, allowing glucose to enter the cell. As a result, glucose utilization and ATP production are enhanced.
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Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
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蛋白质生物异质连接纳米粒子涂层用于动态调节糖尿病微环境.

Lisha Pan1, Ao Zheng1, Ning Huang1

  • 1Department of Prosthodontics, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, Shanghai, 200011, China; National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Engineering Research Center of Advanced Dental Technology and Materials, Shanghai, 200011, China.

Biomaterials
|December 18, 2025
PubMed
概括

这项研究开发了一种新的TiO2/ZnO生物异构连接系统在CFRPEEK牙科植入物上,以改善糖尿病患者的治疗结果. 创新的植入物涂层增强了骨质整合,抗击感染,并管理氧化应激,以获得更好的长期成功.

关键词:
抗菌剂 抗菌剂是一种抗菌剂.抗氧化剂是一种抗氧化剂.生物异质连接生物异质连接糖尿病是一种糖尿病.骨质整合 骨质整合表面的修改是表面的修改.

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科学领域:

  • 生物材料科学 生物材料科学
  • 纳米技术 纳米技术
  • 再生医学是一种再生医学.

背景情况:

  • 糖尿病增加了由于氧化应激和受损愈合而导致牙植入物失败的风险.
  • 现有的抗菌剂可以加剧氧化应激,阻碍骨再生.
  • 糖尿病中高级糖化最终产品 (AGEs) 对植入物骨整合产生负面影响,并增加植入周炎风险.

研究的目的:

  • 为牙科植入物开发一种多功能生物活性涂层,以应对糖尿病患者的挑战.
  • 在CFRPEEK植入物上创建一个TiO2/ZnO生物异构连接 (BJ) 系统,具有协同抗菌,骨质生成和抗氧化特性.
  • 调查改造植入物在调节糖尿病微环境和促进骨质整合方面的有效性.

主要方法:

  • 在CFRPEEK上通过等离子浸泡离子植入 (PIIID-Ti) 制造TiO2接口.
  • 将 ZnO 纳米粒子 (ZnO NPs) 纳入 TiO2 接口,使用聚多巴胺 (PDA) 来形成 TiO2/ZnO BJ.
  • 在糖尿病大鼠股骨缺陷模型中进行了体外和体内评估,以评估生物相容性,抗菌有效性,骨质整合和抗氧化活性.

主要成果:

  • 该TiO2/ZnO BJ系统有效调节了反应性氧物种 (ROS) 水平.
  • 经过修改的表面显示出出色的生物相容性,骨质诱导和早期抗菌疗效.
  • 在体内研究证实了糖尿病大鼠的生物安全性,抗菌能力和增强的骨整合,通过ROS清理和Keap1/Nrf2通路激活.

结论:

  • 经过BJ PIIID-Ti修改的CFRPEEK植入物显示出治疗需要牙科修复的糖尿病患者的巨大潜力.
  • 多功能涂层有效地抵抗感染,并自我调节氧化应激,改善当地的再生微环境.
  • 这种方法为未来临床应用提供了有希望的理论基础,用于在植入式牙科中管理糖尿病并发症.