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蛋白质生物异质连接纳米粒子涂层用于动态调节糖尿病微环境

Lisha Pan¹, Ao Zheng¹, Ning Huang¹

¹Department of Prosthodontics, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, Shanghai, 200011, China; National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Engineering Research Center of Advanced Dental Technology and Materials, Shanghai, 200011, China.

|December 18, 2025

概括

这项研究开发了一种新的TiO2/ZnO生物异构连接系统在CFRPEEK牙科植入物上,以改善糖尿病患者的治疗结果. 创新的植入物涂层增强了骨质整合,抗击感染,并管理氧化应激,以获得更好的长期成功.

科学领域:

生物材料科学生物材料科学
纳米技术纳米技术
再生医学是一种再生医学.

背景情况:

糖尿病增加了由于氧化应激和受损愈合而导致牙植入物失败的风险.
现有的抗菌剂可以加剧氧化应激,阻碍骨再生.
糖尿病中高级糖化最终产品 (AGEs) 对植入物骨整合产生负面影响,并增加植入周炎风险.

研究的目的:

为牙科植入物开发一种多功能生物活性涂层,以应对糖尿病患者的挑战.
在CFRPEEK植入物上创建一个TiO2/ZnO生物异构连接 (BJ) 系统,具有协同抗菌,骨质生成和抗氧化特性.
调查改造植入物在调节糖尿病微环境和促进骨质整合方面的有效性.

主要方法:

在CFRPEEK上通过等离子浸泡离子植入 (PIIID-Ti) 制造TiO2接口.
将 ZnO 纳米粒子 (ZnO NPs) 纳入 TiO2 接口,使用聚多巴胺 (PDA) 来形成 TiO2/ZnO BJ.
在糖尿病大鼠股骨缺陷模型中进行了体外和体内评估,以评估生物相容性,抗菌有效性,骨质整合和抗氧化活性.

主要成果:

该TiO2/ZnO BJ系统有效调节了反应性氧物种 (ROS) 水平.
经过修改的表面显示出出色的生物相容性,骨质诱导和早期抗菌疗效.
在体内研究证实了糖尿病大鼠的生物安全性,抗菌能力和增强的骨整合,通过ROS清理和Keap1/Nrf2通路激活.

结论:

经过BJ PIIID-Ti修改的CFRPEEK植入物显示出治疗需要牙科修复的糖尿病患者的巨大潜力.
多功能涂层有效地抵抗感染,并自我调节氧化应激,改善当地的再生微环境.
这种方法为未来临床应用提供了有希望的理论基础,用于在植入式牙科中管理糖尿病并发症.

关键词:

抗菌剂抗菌剂是一种抗菌剂.抗氧化剂是一种抗氧化剂.生物异质连接生物异质连接糖尿病是一种糖尿病.骨质整合骨质整合表面的修改是表面的修改.

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