基于电荷的超分子纳米复合体,可通过输送器驱动的内细胞酶通过口服输送
So-Hyeon Park1, Gaeun Ma1, Seong Jin Park2
1Department of Applied Life Science, BK21 Program, Konkuk University, Chungju, 27478, Republic of Korea.
Biomaterials
|December 18, 2025
概括
我们开发了新的带正电荷的基工程胆汁酸 (PCBs),可以与半谷氨酸 (SG) 自组装成稳定的纳米粒子. 这一突破增强了SG的口服输送,用于治疗肥胖和糖尿病.
科学领域:
- 生物材料科学 生物材料科学
- 纳米技术 纳米技术
- 药物运输 药物运输 药物运输
背景情况:
- 由于吸收不良,口服输送的治疗药物,如Semaglutide (SG) 是具有挑战性的.
- 自组装的超分子纳米结构为改善药物输送提供了潜力.
- 胆汁酸可以通过载体介导机制促进肠道吸收.
研究的目的:
- 开发新的带正电荷的基胆酸 (PCB) 用于口服赛马格卢提德 (SG) 输送.
- 创建稳定的超分子纳米粒子,以提高肠道吸收.
- 为了在体内评估这些新型纳米复合物的治疗疗效.
主要方法:
- 合成和表征带正电荷的基工程胆汁酸 (PCB).
- 带有负电荷的半质 (SG) 的PCB自组装成超分子纳米粒子 (PBSG).
- 在实验室中评估纳米颗粒的透性和通过内细胞分裂 (endocytosis) 的细胞吸收.
- 在体内评估口服吸收,高脂肪饮食模型中的治疗疗效,以及GLP-1表达.
主要成果:
- 有正电荷的胆汁酸和性黄化物 (PBSG) 纳米复合物成功形成 (~279 nm).
- PBSG纳米复合体通过胆汁酸载体驱动的内细胞酶增强了肠道的透性和吸收.
- 口服PBSG治疗改善了塞马格卢提德的治疗疗效,增加了GLP-1表达,并调节了胆酸代谢.
结论:
- 基于电荷的PCB与SG的自组装为口服化纳米粒子输送提供了一个可行的策略.
- 输送器驱动的内细胞分裂显著增强了塞马格卢提德的口服吸收.
- 这种方法在设计用于口服的治疗纳米材料方面取得了重大进展.
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