打破阻力循环:高热性堆肥建立了对ARG传播的多层防御
Xu Li1, Yanping Zhang1, Chaoyue Zhao1
1Institute of Process Equipment and Environmental Engineering, School of Mechanical Engineering and Automation, Northeastern University, Shenyang 110819, China.
Journal of hazardous materials
|December 18, 2025
概括
高热性堆肥 (>80°C) 有效地从牲畜中去除抗生素残留物和抗生素耐药基因 (ARG). 这种方法建立了强大的阻抗障碍,为便管理和公共卫生保护提供了更安全的途径.
科学领域:
- 环境科学 环境科学
- 微生物学 微生物学
- 公共卫生 公共卫生
背景情况:
- 牲畜中的抗生素残留物和抗生素耐药性基因 (ARG) 构成重大公共卫生风险.
- 传统的堆肥方法可能无法完全减轻这些环境污染物.
研究的目的:
- 与传统堆肥 (CK) 相比,使用高热友化堆肥 (HC) 调查抗生素和ARG去除机制.
- 评估极端温度对微生物群落,抗生素降解以及ARG/MGE动态的影响.
主要方法:
- 已建立的高热性堆肥 (HC,>80°C) 和传统堆肥 (CK) 系统.
- 综合元基因组学,定量PCR (qPCR) 和机器学习 (PLS-PM,随机森林).
- 分析了抗生素残留物,ARG/MGE丰富度,微生物群落结构和化指数.
主要成果:
- 碳化合物迅速达到高温,并显著增强有机物降解和化.
- HC证明了关键抗生素 (oxytetracycline,enrofloxacin,sulfamethoxazole) 的有效去除,并大大减少了ARG和MGE的丰度.
- 机器学习模型将MGE确定为ARG传播的主要驱动因素,温度通过微生物社区重组间接影响这一点.
结论:
- 与传统方法相比,高热性堆肥提供了一种更优越,更快速,更稳定的方法,可以减轻牲畜中的抗生素耐药性风险.
- 高化物创造了涉及高温,微生物转移和MGE抑制的多层屏障,促进了安全的肥价值化和支持One Health框架.
相关概念视频
00:57Antibiotic Selection
59.3K
Overview
59.3K
01:30Development of Antibiotic Resistance
1.1K
Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
1.1K
01:21Hyperthermophilic Bacteria
451
Domain Bacteria includes some unique hyperthermophilic species. They exhibit remarkable adaptations that enable survival in extreme environments.Thermotoga species are rod-shaped, gram-negative, non-sporulating hyperthermophiles that form a sheath-like envelope called a toga. They ferment sugars or starch, producing lactate, acetate, CO₂, and H₂, and can also grow via anaerobic respiration using H₂ and ferric iron. Found in hot springs and hydrothermal vents, over 20% of their...
451
01:26Transformation
644
Microbial communities are dynamic environments where cell lysis releases free DNA into the surroundings. Other cells can take up this extracellular DNA through a process known as transformation.When a cell incorporates this foreign DNA into its genome, resulting in genetic modification, the process is known as transformation. Cells capable of this process are termed competent. Competence can be natural, as observed in certain bacteria and archaea, or artificially induced in the...
644
01:30Diversity of Archaea I
504
Archaea, a domain of single-celled microorganisms, are classified into five major phyla based on genetic and biochemical characteristics: Euryarchaeota, Crenarchaeota, Thaumarchaeota, Korarchaeota, and Nanoarchaeota. Among these, the phylum Euryarchaeota is notable for its remarkable diversity in morphology, metabolism, and ecological adaptations.Morphological and Metabolic DiversityMembers of Euryarchaeota exhibit a variety of cellular shapes, including rods and cocci. Their metabolic pathways...
504
01:28Gene Regulation in Microbial Communities: Quorum Sensing
463
Quorum sensing is a mechanism of bacterial communication that enables coordinated gene expression in response to changes in population density. This facilitates collective behaviors that enhance survival, resource acquisition, and ecological adaptation. This process relies on small signaling molecules called autoinducers that accumulate as bacterial populations grow. When a critical threshold concentration of autoinducers is reached, bacterial cells collectively modify gene expression,...
463