空气污染和加速表观遗传衰老:来自台湾生物库的多个表观遗传钟的证据
Chi-Fung Cheng1, Chi-Shin Wu2, Ta-Chien Chan3
1National Center for Geriatrics and Welfare Research, National Health Research Institutes, Miaoli, Taiwan.
Journal of hazardous materials
|December 18, 2025
概括
暴露于细颗粒物 (PM2.5) 和粗颗粒物 (PM10) 显著加速表观遗传衰老. 这些空气污染物是生物衰老的关键驱动因素,凸显了对污染控制的公共卫生需求.
科学领域:
- 环境健康 环境健康
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 衰老研究研究 衰老研究
背景情况:
- 表观遗传加快年龄是生物衰老的标志物.
- 环境空气污染对表观遗传衰老的影响需要进一步研究.
研究的目的:
- 检查暴露于六种常见的空气污染物和表观遗传衰老加速之间的关联.
- 用多个表观遗传钟来确定哪些特定的空气污染物与表观遗传衰老最为密切相关.
主要方法:
- 利用台湾生物银行2462名参与者的数据.
- 评估暴露在PM2.5,PM10,CO,NO2,SO2和O3中的情况.
- 应用了三个不同的表观遗传钟 (Horvath,BLUP,EN) 来测量DNA甲基化年龄.
主要成果:
- 暴露于PM2.5和PM10都与所有三个表观遗传时钟有显著的关联.
- 这些关联在多污染物模型中仍然存在.
- 重量分布分析确定PM2.5和PM10是表观遗传衰老加速的主要贡献者.
结论:
- 空气污染,特别是PM2.5和PM10,与加速表观遗传衰老有关.
- 减少这些颗粒物暴露对于促进健康老龄化和公共卫生战略至关重要.
更多相关视频
05:18Measuring Carbon Content in Airway Macrophages Exposed to Carbon-Containing Particulate Matters
Published on: July 12, 2024
674
12:15Quantification of three DNA Lesions by Mass Spectrometry and Assessment of Their Levels in Tissues of Mice Exposed to Ambient Fine Particulate Matter
Published on: May 29, 2019
9.1K
相关概念视频
01:26Aging
566
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
566
01:19The Effect of Aging on Tissues
3.1K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
3.1K