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在母体微生物群,牛奶成分和婴儿肠道微生物群之间的特定时间的双向联系
Lishi Deng1, Kelsey Fehr2, Laeticia Celine Toe3
1Department of Food Technology, Safety and Health, Faculty of Bioscience Engineering, Ghent University, Ghent, Belgium.
Cell host & microbe
|December 18, 2025
概括
母亲因素,如肠道和牛奶微生物,影响婴儿肠道微生物组的发展. 早期婴儿的肠道特征甚至可能会向母亲发出信号,影响牛奶成分.
科学领域:
- 微生物组研究的研究.
- 母婴健康 孕产妇和婴儿健康
- 人类哺乳期 哺乳期
背景情况:
- 早期的肠道微生物组发育受到母亲和营养因素的影响.
- 母亲和婴儿微生物组之间的时间动态和定向相互作用尚未得到充分理解.
- 了解这些相互作用对于开发有针对性的干预措施至关重要.
研究的目的:
- 研究母亲的肠道和牛奶微生物组以及牛奶成分如何塑造婴儿在前六个月的肠道微生物组发育.
- 探索母亲和婴儿微生物组和牛奶成分之间的时间关系和潜在的双向通信.
主要方法:
- 在布基纳法索农村地区对152个母婴双进行了纵向研究.
- 分析母亲的肠道和牛奶微生物组.
- 牛奶成分 (寡糖和其他营养素) 的量化.
- 在最初的六个月内,婴儿肠道微生物组发展的特征.
主要成果:
- 婴儿肠道微生物组在1-2个月时分为三种不同的类型:以斯赫里希亚菌为主,以Bifidobacterium为主,以及多样化,病原体普遍的特征.
- 这些早期婴儿肠道特征与母亲的产前肠道微生物群和早期牛奶微生物群和寡糖有关.
- 后来,婴儿肠道微生物组的变化与其他牛奶营养素有关.
- 早期婴儿的肠道微生物组概况预测了随后的牛奶成分,表明了潜在的双向信号传输.
结论:
- 母亲的肠道和牛奶微生物组,以及牛奶成分,显著影响婴儿早期肠道微生物组的发展.
- 婴儿的肠道微生物组和母亲的哺乳生理之间可能存在双向通信.
- 研究结果提供了对早期微生物发育的见解,并为针对微生物的干预提供了信息,特别是在资源有限的环境中.
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