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Updated: Jan 8, 2026

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在Cynomolgus Macaque (Macaca fascicularis) 中通过皮肤注射布普伦诺芬局部溶液的药理动力学

Emma L Santoro1, Jeffrey D Fortman1, Kristen M Messenger2

  • 11Biologic Resources Laboratory, University of Illinois Chicago, Chicago, Illinois.

Journal of the American Association for Laboratory Animal Science : JAALAS
|December 18, 2025
PubMed
概括

一种新的透皮布普伦诺芬局部溶液为研究灵长类动物提供了有效的疼痛管理. 这种侵入性较小的方法至少维持72小时的治疗水平,改善了动物福利.

关键词:
AUC0-Tlast,从零时间到最后一个时间点的曲线下的面积.AUC0-∞,从零时到无限时的曲线下的面积.CL, 清除时间.F,生物可用性 生物可用性MRT,平均居住时间.药理学,药理动力学Tlast,最后一个可量化的血分析物度的时间.Vss,稳定状态下的分布体积.λz,是消除速率常数.

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