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卵巢癌的检测和预后:揭示潜在的circRNAs

Mehran Molavand¹, Amir Valizadeh¹, Bahman Yousefi²

¹Department of clinical Biochemistry and Laboratory Medicine, Faculty of Medicine, Tabriz University of Medical science, Tabriz, Iran; Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.

Clinica chimica acta; international journal of clinical chemistry

|December 18, 2025

概括

循环RNAs (circRNAs) 显示为卵巢癌检测和预后的生物标志物具有前途. 它们的稳定性和体液中可测量的丰富性为早期诊断和治疗监测提供了新的希望.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
生物化学生物化学

背景情况:

卵巢癌是一种高度侵略性的恶性瘤,由于晚期检测和治疗耐药性,其结果不佳.
目前对卵巢癌的诊断和预后工具有限,需要新的生物标志物.
循环RNAs (circRNAs) 是稳定的RNA分子,具有作为生物标记物的潜力.

研究的目的:

综合审查关于卵巢癌中circRNAs诊断和预后价值的最新发现.
分析circRNAs作为生物标记物的分子机制和临床应用.
更新对卵巢癌检测和结果预测中的circRNAs的理解.

主要方法:

在没有语言限制的情况下,从主要科学数据库中对数据进行系统审查.
分析与卵巢癌中circRNAs相关的分子和临床发现.
评估circRNA表达模式及其与临床病理特征的相关性.

主要成果:

基于circRNA表达的生物标记面板在检测卵巢癌时达到0.923的AUC.
特定的circRNA与整体存活率,组织学等级和瘤负担相关.
循环RNAs表现出稳定性,体液中的丰富性和卵巢癌的失调性.

结论:

循环RNA具有显著的潜力,作为卵巢癌的敏感,特异性和最小侵入性生物标志物.
这些生物标志物可以帮助早期检测,准确的预后,并监测治疗反应.
对circRNAs的进一步研究可能会彻底改变卵巢癌的治疗.

关键词:

循环的RNA是循环的RNA.诊断诊断诊断诊断诊断早期检测早期检测卵巢癌是发生在卵巢中的癌症.预测预测预测预测

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lncRNA - Long Non-coding RNAs

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...