口腔状细胞癌中的分子标记:洞察瘤微环境,表观遗传调节和细胞间通信
Xiaoran Zhen1, Dongyan Zhang2, Dongbao Li2
1School of Stomatology, Shandong Second Medical University, Weifang, Shandong 261053, PR China.
Biochimica et biophysica acta. Reviews on cancer
|December 18, 2025
概括
本综述探讨了口腔状细胞癌 (OSCC) 的新生物标志物,重点关注瘤微环境 (TME) 和表观遗传变化. 它强调了细胞外囊泡 (EV) 和高通量技术,以了解OSCC的进展.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 生物化学 生物化学
背景情况:
- 口腔状细胞癌 (OSCC) 是一种影响口腔粘膜的流行恶性瘤.
- 了解OSCC进展需要了解其复杂的瘤微环境 (TME).
- 表观遗传改变在OSCC的发展和进步中起着至关重要的作用.
研究的目的:
- 审查最近在识别OSCC新生物标志物的进展.
- 调查TME在OSCC中的作用,包括免疫逃避,矩阵重塑和血管生成.
- 探索表观遗传修饰和细胞外囊泡 (EVs) 对OSCC进展的影响.
主要方法:
- 文献综述侧重于最近在OSCC生物标志物发现方面的研究.
- 分析TME组件及其在OSCC病原发生中的参与.
- 在OSCC.中研究表观遗传变化 (DNA甲基化,基因组修饰,非编码RNA).
- 检查细胞外囊泡 (EVs) 在TME内的细胞间通信中的作用.
- 讨论高通量技术,如单细胞测序和质谱等.
主要成果:
- 对于OSCC的新生物标志物正在从TME组件和表观遗传修饰中出现.
- 通过免疫逃避,矩阵重塑和血管生成,TME显著促进OSCC.
- 包括非编码RNA在内的表观遗传变化是OSCC进展的关键驱动因素.
- 细胞外囊泡 (EVs) 作为关键调解者,将TME与表观遗传调节联系起来.
- 高通量技术在阐明OSCC的分子机制方面发挥了重要作用.
结论:
- 识别新的OSCC生物标志物需要了解TME动态和表观遗传景观.
- 准TME组件和表观遗传途径对OSCC具有治疗潜力.
- 细胞外囊泡 (EVs) 是OSCC研究和诊断的一个有希望的领域.
- 先进的技术对于OSCC的全面分子分析至关重要.
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