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作为微塑料诱导的骨损失的治疗点的RANKL/OPG轴:来自转录和功能验证的机制见解

Weilin Zhang¹, Kuize Liu¹, Boyuan Zhou¹

¹Department of Spinal Degeneration and Deformity Surgery, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, 524023, China.

Toxicology letters

|December 18, 2025

概括

微塑料 (MP) 存在于人类骨组织中,影响骨健康. 这项研究揭示了MPs通过促进骨质细胞分化来破坏骨代谢,突出了干预的必要性.

科学领域:

环境科学环境科学
毒理学毒理学毒理学
生物医学工程生物医学工程

背景情况:

塑料产品降解为微塑料 (MP),对生态系统和人类健康构成风险.
对MPs在人体组织中的积累和影响存在担忧.

研究的目的:

为了调查人类骨组织中微塑料的存在.
阐明微塑料对骨代谢和相关信号通路的影响.

主要方法:

使用尼罗河红色染色,拉曼光谱和红外显微光谱分析人类骨样本.
用聚乙烯微塑料 (MP-PE) 养的小鼠的股骨组织的转录形状分析.
在骨髓 stromal 细胞和 Raw264.7 细胞的体外研究,以评估骨质细胞分化.

主要成果:

在40个人类骨样本中的33个中发现了微塑料颗粒,主要是聚乙烯和聚烯 (10-20微米).
转录组分析揭示了MP-PE食小鼠的显著基因表达变化,涉及造血,NF-κB,PPAR,PI3K-Akt和HIF-1信号通路.
在体外实验表明,MPs通过RANKL/OPG轴和RANK-NFATc1通路增强骨质细胞分化.

结论:

微塑料存在于人类骨组织中,可以对骨代谢产生负面影响.
MPs促进骨质细胞分化,可能导致对骨健康的有害影响.
迫切需要采取环境和公共卫生干预措施,以应对微塑料污染.

关键词:

人类骨组织人类骨组织豁免权是一种豁免权.微塑料是一种微塑料.兰克尔 (Rankel) /OPG (OPG) 是一个名字.转录基因组序列的测序

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