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在双胞胎怀孕的样本大小计算中对二元结果的类内相关系数估计器进行比较
Peter M Socha1, Tim D'Aoust2, Erica Em Moodie1
1Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Quebec, Canada.
Annals of epidemiology
|December 18, 2025
概括
对于双胞胎怀孕研究,逻辑通用线性混合模型 (GLMM) 可能会膨胀样本大小计算. 其他类内相关系数 (ICC) 估计器提供准确的样本大小,以实现所需的统计能力.
科学领域:
- 生物统计学 生物统计学
- 流行病学 流行病学
- 生殖健康 生殖健康
背景情况:
- 类内相关系数 (ICC) 对于集群研究设计中的样本大小计算至关重要.
- 根据所选择的统计方法,对ICC的估计可能会有很大差异,特别是对二元结果的估计.
- 准确的样本大小确定对于在研究研究中获得足够的统计能力至关重要.
研究的目的:
- 在双胞胎怀孕研究的样本大小计算中评估五种常见的类内相关系数 (ICC) 估计器的性能.
- 确定哪些ICC估计方法可靠地实现所需的统计能力 (80%),I型错误率为5%.
- 为了比较基于从物流GEE,ANOVA,LMM和物流GLMM获得的ICC的样本大小计算.
主要方法:
- 模拟双胞胎怀孕研究,具有不同的集群水平和结果流行率.
- 使用基于物流GEE,ANOVA,LMM和物流GLMM的ICC估计的标准公式计算样本大小.
- 通过模拟评估经验功率,以验证计算样本大小的准确性.
主要成果:
- 来自GEE,ANOVA和LMM的ICC估计是一致的,并在不同的结果流行率中产生了准确的样本大小.
- 由物流GLMM衍生的ICC估计显示出随着结果流行率的变化.
- 后勤GLMM导致过大的样本大小计算,特别是高集群或低结果流行率,导致膨胀的功率.
结论:
- 对于双胞胎怀孕研究中的样本大小计算,应谨慎使用基于GLMM的物流ICC估计.
- 在这些研究中,GEE,ANOVA和LMM为样本大小的确定提供了更可靠的ICC估计.
- 选择合适的ICC估计器对于集群研究设计中有效和准确的样本大小规划至关重要.
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