扩散性结质瘤瘤切除后的早期术后静脉血栓栓塞:诊断和预防症状性静脉血栓塞的含义
Yoshinari Osada1, Masayuki Kanamori1, Shota Yamashita1
1Department of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, Japan.
World neurosurgery
|December 18, 2025
概括
静脉血栓栓塞 (VTE) 在质瘤手术后很常见,早期诊断至关重要. 溶性纤维素单体复合物 (SFMC) 有助于在质母细胞瘤患者中检测VTE,防止进展.
科学领域:
- 神经外科 神经外科
- 在瘤学瘤学.
- 血管医学 血管医学
背景情况:
- 经过质瘤切除的患者面临着高风险的静脉血栓塞栓症 (VTE).
- 在这种患者群体中,早期诊断和预防VTE至关重要.
- 由于潜在的术后并发症,扩散性质瘤是一个重大挑战.
研究的目的:
- 在扩散性瘤切除后的术后第一天 (POD1) 调查静脉瘤发病率.
- 评估血溶性纤维素单体复合物 (SFMC) 和D-二元水平对VTE的查有效性.
- 分析扩散性结质瘤患者的静脉瘤管理结果.
主要方法:
- 81名接受扩散性质瘤切除 (2021-2023) 的患者的回顾性分析.
- 在POD1.1上使用D-二聚合物和SFMC水平进行VTE查.
- 通过增强型计算机断层扫描进行静脉瘤诊断;通过机械预防和抗凝药进行管理.
主要成果:
- 在81名患者中,有33名患者 (40.7%) 被诊断为VTE,主要是无症状的 (31名患者).
- D-二次体和SFMC的正预测值分别为83%和68%;SFMC没有显著改善D-二次体的假阳性.
- 在3名质母细胞瘤患者中,SFMC发现了虚阴性D-二次体结果的静脉瘤;没有无症状的静脉瘤进展.
结论:
- 无症状的VTE在扩散性质瘤切除后经常发生在POD1上.
- 早期诊断和治疗VTE可以防止疾病进展为症状性疾病.
- SFMC水平显示出改善静脉瘤检测的潜力,特别是在质母细胞瘤患者中.
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