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Updated: Jan 8, 2026

Detection of Signaling Effector-Complexes Downstream of BMP4 Using in situ PLA, a Proximity Ligation Assay
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Detection of Signaling Effector-Complexes Downstream of BMP4 Using in situ PLA, a Proximity Ligation Assay

Published on: March 3, 2011

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对OXGR1的配体识别和信号传递的分子洞察力

Aijun Liu1,2, Yezhou Liu3, Yuanzhengyang Long3

  • 1The Affiliated Dongguan Songshan Lake Central Hospital, Guangdong Medical University, Dongguan, Guangdong, China. liuaijun@cuhk.edu.cn.

Nature communications
|December 18, 2025
PubMed
概括

G蛋白结合受体 (GPCR) GPR99/OXGR1通过单独的结合部位结合了两个不同的配体,即2-oxoglutarate和cysteinyl leukotriene E4 (LTE4). 低温电磁结构显示出独特的结合口袋,使双联体识别和差异信号通路成为可能.

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