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当地治疗平台通过减少GIC和重塑免疫抑制微环境,防止术后GBM复发

Mengxi Zhu1,2, Mengting Yang1,3, Rui Li1,2

  • 1Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics, School of Pharmacy, Tianjin Medical University, Tianjin, China.

Nature communications
|December 18, 2025
PubMed
概括

这项研究引入了一种新的可注射平台,用于对抗多形质母细胞瘤 (GBM) 复发. 该疗法向剩余的质瘤发起细胞 (GIC),并扭转了手术后的免疫抑制瘤微环境.

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Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.