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Xiaoxu Li1, Alessia Perino2, Jonathan Sulc1
1Laboratory of Integrative Systems Physiology, Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
Nature communications
|December 18, 2025
概括
遗传和饮食因素显著影响肠道微生物群和胆酸 (BA) 交叉 (gMxB). 研究人员确定了特定的基因位置和候选基因 (PTGR1,PTPRD) 影响这一关键的肠-宿主通信通路.
科学领域:
- 微生物学 微生物学
- 遗传学 是一个遗传学.
- 代谢学 代谢学 代谢学
背景情况:
- 肠道微生物群在宿主生理学中起着至关重要的作用,通过微生物代谢物如二次胆汁酸 (BAs) 进行通信.
- 肠道微生物群 - 胆酸交叉 (gMxB) 的复杂机制在很大程度上仍未被探索.
- 了解gMxB对于破译肠道与宿主之间的沟通及其对健康的影响至关重要.
研究的目的:
- 研究遗传和饮食因素如何调节肠道微生物群及其与胆汁酸 (gMxB) 的交叉声.
- 确定参与调节gMxB.B.的遗传基因位置和候选基因.
- 探索已识别的gMxB调节器在代谢健康中的人类相关性.
主要方法:
- 在不同饮食下对BXD小鼠的食后肠微生物组,BA水平和结肠转录组的分析.
- 应用系统遗传学的方法来识别与gMxB.相关的饮食依赖的遗传位点.
- 与人类数据库 (MiBioGen,英国生物银行,FinnGen,百万老兵计划) 的整合,以优先考虑和验证候选基因.
主要成果:
- 发现遗传和饮食因素显著改变了微生物组合,并影响了gMxB.
- 确定了四个与gMxB相关的饮食依赖的共同映射遗传位置,包括Turicibacter sanguinis和血胆酸之间的特定相互作用.
- 优先考虑PTGR1和PTPRD作为潜在调节gMxB的候选基因,研究它们与人类代谢健康的相关性.
结论:
- 这项研究揭示了影响gMxB的关键调节器,突出了宿主基因,饮食和肠道微生物组之间的相互作用.
- 这些发现为通过胆汁酸进行肠道微生物群与宿主沟通的复杂机制提供了新的见解.
- 已识别的候选基因为未来对代谢健康干预的研究提供了潜在的目标.
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