与低密度脂蛋白胆固醇相比,残留胆固醇在心血管风险评估中的新兴重要性
Farzam Kamrani1, Mobina Imannezhad1, Ali Rezaee2
1Department of Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran.
Scientific reports
|December 18, 2025
概括
剩余胆固醇 (RC) 和LDL-C是心血管疾病 (CVD) 的关键风险因素. 高RC水平显著增加心血管疾病和冠状动脉疾病 (CAD) 的风险,即使LDL-C低.
科学领域:
- 心脏病学 心脏病学
- 脂质代谢 脂质代谢是什么
- 预防医学 预防医学
背景情况:
- 剩余胆固醇 (RC) 是心血管疾病 (CVD) 的新兴风险因素.
- 它的临床意义正在获得认可,可能会超过传统的脂质标记物,如LDL-C.
- 了解RC和LDL-C之间的相互作用对于准确的心血管疾病风险评估至关重要.
研究的目的:
- 调查残留胆固醇 (RC) 和低密度脂蛋白胆固醇 (LDL-C) 的一致和不一致水平之间的关联.
- 检查心血管疾病,冠状动脉疾病 (CAD),缺血性中风和心血管疾病死亡率与RC和LDL-C水平相关的发病率.
- 确定RC和LDL-C的预测值,单独和组合,对于心血管事件.
主要方法:
- 一项为期10年的前性队列研究,涉及伊朗东北部的9704名参与者.
- 进行了LDL-C和RC的基线测量.
- 参与者根据RC (<24 mg/dL或≥24 mg/dL) 和LDL-C (<130 mg/dL或≥130 mg/dL) 水平进行分类.
- 考克斯回归分析用于评估心血管疾病,CAD,中风和死亡率的风险.
主要成果:
- 升高的RC (≥24 mg/dL) 与CVD和CAD的风险显著增加有关,无论LDL-C水平如何.
- 与高RC和低LDL-C的人相比,高RC和低LDL-C的人患心血管疾病和CAD的风险更高.
- 高的LDL-C与低的RC也增加了心血管疾病和CAD风险,但高的RC与低的LDL-C提供了更强大的风险预测.
- 在RC/LDL-C水平和缺血性中风或心血管疾病死亡率之间没有发现显著的关联.
结论:
- 升高的残留胆固醇 (RC) 和LDL胆固醇 (LDL-C) 都是心血管疾病 (CVD) 和冠状动脉疾病 (CAD) 的重要预测因素.
- 剩余胆固醇在心血管风险分层中发挥着关键作用,比单独的LDL-C提供了更好的预测价值,特别是当RC升高而LDL-C不升高时.
- 需要进一步的研究来阐明这些脂质参数与缺血性中风或心血管疾病死亡率之间的关系.
相关概念视频
Cholesterol: Significance and Regulation
1.2K
Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
Considering cholesterol and...
1.2K
Blood Studies for Cardiovascular System III: Serum Lipid Profile
534
Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
534
Lipids: Dietary Sources and Requirements
1.8K
Lipids are an essential component of a balanced human diet. Triglycerides, which make up the majority of dietary lipids, are found in both saturated fats—commonly present in meat, dairy products, and certain tropical plants like coconut, and hydrogenated oils such as margarine and baking shortenings (trans fats)—and unsaturated fats, which are abundant in seeds, nuts, olive oil, and most vegetable oils. The main sources of cholesterol include egg yolks, various meats and organ...
1.8K
Coronary Artery Disease IV: Preventive Measures
572
Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
572
Atherosclerosis III: Management
293
Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
293
Lipid-derived Compounds in the Human Body
6.2K
Fats and lipids are crucial components in the human body. Some lipid-derived compounds, such as fat-soluble vitamins, eicosanoids, lipoproteins, and glycolipids, also play unique roles to support various biological processes .
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin,...
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin,...
6.2K


