系统性免疫炎症指数与类风湿性关节炎患者的疾病活性得分28之间的关联:一个横截面研究
Xiaoli Li1, Lina Leng1, Yaorong Han1
1Department of Rheumatology, Xingtai people's Hospital, Xingtai, 054001, Hebei Province, China.
Scientific reports
|December 18, 2025
概括
系统性免疫炎症指数 (SII) 与类风湿性关节炎 (RA) 疾病活性正相关,特别是DAS28-ESR和DAS28-CRP,在SII高于260.36.6的患者中. 这表明SII是一种有价值的生物标志物,用于评估中度至高疾病活动病例中的RA严重程度.
科学领域:
- 类风湿病学 类风湿病学
- 免疫学 免疫学 免疫学
- 生物标志物 生物标志物
背景情况:
- 系统性免疫炎症指数 (SII) 与类风湿性关节炎 (RA) 疾病活性之间的关联需要进一步阐明.
- 了解这种关系对于精确的RA患者管理至关重要,特别是在中度至高疾病活性患者中.
研究的目的:
- 调查系统性免疫炎症指数 (SII) 与住院类风湿关节炎 (RA) 患者的疾病活性之间的相关性.
- 为了确定与RA疾病活动指标相关的SII的潜在值.
主要方法:
- 分析了997名住院RA患者的队列,主要是中度至高度的疾病活动.
- 使用疾病活动评分28-红细胞沉积率 (DAS28-ESR) 和C反应蛋白 (DAS28-CRP) 来评估疾病活动.
- 非线性回归模型,包括通用添加模型,用于在SII的自然对数转换后探索SII和疾病活动之间的关联.
主要成果:
- 在SII和RA疾病活性之间观察到非线性关系,在SII>260.36 (LnSII = 5.56) 确定了显著值.
- 在这个值以上,SII与DAS28-ESR (β = 0.53) 和DAS28-CRP (β = 0.63) 都显示出显著的正相关性.
- 在确定值以下的SII和疾病活动之间没有发现显著的关联.
结论:
- 系统性免疫炎症指数 (SII) 独立且积极地与RA患者的DAS28-ESR和DAS28-CRP相关,SII水平超过260.36.
- SII可以作为一个有价值的生物标志物来评估RA患者的疾病活性,特别是那些呈现中度至高疾病活性的人.
- 这些发现强调了SII在临床实践中对RA严重程度评估的有用性.
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