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缺氧诱导的VEGF分泌促进对双特异性T细胞参与剂的抵抗

Mengyao Xu1, Syem K Barakzai2, Raj Kumar1

  • 1Massachusetts General Hospital Cancer Center, Boston, MA, USA.

Signal transduction and targeted therapy
|December 18, 2025
PubMed
概括

低氧导致卵巢癌中对双特异性T细胞参与因子 (BITE) 的耐药性,通过降低MUC16/CA125和增加VEGF. 将VEGF抑制剂与BITE结合起来可以克服这种抗性,改善免疫治疗结果.

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