干白素-27在母胎界面对寨卡病毒具有抗病毒作用
Madeline S Merlino1, Briah Barksdale1, Seble G Negatu1
1Department of Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Nature communications
|December 18, 2025
概括
洲际蛋白-27 (IL-27) 是一个新型的胎盘内在抗病毒防御. IL-27信号限制了寨卡病毒感染,在怀孕期间保护胎儿的结果.
科学领域:
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
- 生殖生物学 生殖生物学
背景情况:
- 先天性病毒感染对怀孕和胎儿发育构成重大风险.
- 胎盘充当感染的屏障,由免疫细胞和细胞因子调节.
- 干白素-27 (IL-27) 在母胎界面的具体作用基本上是未知的.
研究的目的:
- 研究IL-27在胎盘防御病毒感染中的作用.
- 为了确定IL-27信号是否影响胎盘细胞中的寨卡病毒限制.
- 在先天性病毒感染模型中评估IL-27的治疗潜力.
主要方法:
- 从胎盘组织中获得的使用的人类热囊细胞器官.
- 进行了大量的RNA测序,以分析IL-27信号传递的基因表达变化.
- 采用一种先天性寨卡病毒感染的小鼠模型来评估IL-27的体内功能.
主要成果:
- 人类胎盘热囊细胞有机体表达IL-27及其受体.
- IL-27信号被证明可以限制热囊细胞有机体中的寨卡病毒感染.
- 在胎盘细胞内,IL-27上调了关键的抗病毒基因.
- 在小鼠模型中,IL-27信号显著降低了胎盘病毒载量,并保护了胎儿病理.
结论:
- IL-27在人胎盘中构成性表达,并作为一种先天的抗病毒因子起作用.
- IL-27信号传递对胎盘防御病毒入侵和维持健康的胎儿结果至关重要.
- 这项研究确定IL-27是母胎界面抗病毒免疫的关键组成部分.
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