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关于大鼠胰腺头尾小岛细胞中MiRNA表达的异质性研究

Xuehua Lu1, Yunlu Liu2, Jinyan Chen3

  • 1Fujian Key Laboratory of Medical Analysis, Fujian Academy of Medical Sciences, Fuzhou, China.

BMC medical genomics
|December 18, 2025
PubMed
概括

胰腺小岛细胞在头和尾之间显示出明显的微RNA (miRNA) 表达. 这种异质性影响胰腺癌和胰岛素耐药性相关的途径,提供了新的治疗点.

关键词:
异质性 异质性 异质性在 MiR-124-3p 机器人.胰腺的头部 胰腺的头部胰腺的尾巴 胰腺的尾巴

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MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...