在学龄前儿童的炎症指标和骨矿物质密度之间的关系
Ying Hu1, Xue-Yi Jin1, Xue-Qian Mao1
1Department of Epidemiology and Statistics, School of Public Health, Lanzhou University, Lanzhou, China.
Pediatric research
|December 18, 2025
概括
像PIV,SII和NLR这样的炎症标志物与学龄前儿童的骨矿物质密度 (BMD) 的增加有关. 在这个年龄组中,PIV显示出预测低BMD风险的潜力.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 炎症和免疫学 炎症和免疫学
- 骨的新陈代谢 骨的新陈代谢
背景情况:
- 骨矿物质密度 (BMD) 对儿童的骨健康至关重要.
- 了解影响儿科BMD的因素对于早期干预至关重要.
- 炎症标志物在儿科骨健康中的作用需要进一步研究.
研究的目的:
- 探索在学龄前儿童的炎症指标和BMD之间的关联.
- 为了识别潜在的炎症标志物来预测BMD不足.
- 研究儿童炎症和骨代谢标志物之间的关系.
主要方法:
- 研究了一组393名学龄前儿童 (4-6岁) 的队列.
- 炎症指标 (NLR,PLR,SII,PIV) 是从全血细胞计计算出来的.
- 使用了共差分析,ROC曲线分析和多重线性回归.
主要成果:
- NLR,PIV和SII显示出与骨质量增加的积极关联.
- PIV和SII显示了低BMD (AUC>0.55) 的预测能力.
- PIV与骨质卡尔和25(OH) D正相关;SII与骨质卡尔相关.
结论:
- NLR,SII和PIV与学龄前儿童的BMD增加有关.
- PIV成为预测BMD缺陷风险的一个有希望的工具.
- 研究结果表明,慢性炎症在儿科骨健康中起着独特的作用.
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