在晚期肺癌中,移动性,社会参与和症状负担之间的相互作用
Carmine Petrasso1, Joanne Bayly2, Lucy Fettes3
1Cicely Saunders Institute of Palliative Care, Policy and Rehabilitation, King's College London, Bessemer Road, SE5 9PJ, London, UK. carmine.1.petrasso@kcl.ac.uk.
概括
在晚期非小细胞肺癌 (NSCLC) 中,尽管移动性稳定且症状负担较重,但随着时间的推移,参与度有所改善. 基线症状负担预测了移动性变化,突出了其在NSCLC患者康复中的作用.
科学领域:
- 在瘤学瘤学.
- 康复医学 康复医学 康复医学
- 生活质量研究 研究 生命质量研究
背景情况:
- 晚期非小细胞肺癌 (NSCLC) 由于高症状负担,严重影响患者的日常功能和生活质量.
- 了解移动性,参与和症状负担的进展对于NSCLC有效的康复策略至关重要.
- 纵向数据可以阐明这些因素在整个疾病进展过程中的复杂相互作用.
研究的目的:
- 描述和比较高级NSCLC患者的运动,参与和症状负担的纵向轨迹.
- 评估移动性,参与和症状负担变化之间的关联.
- 确定这种患者群体中移动性变化的预测因素.
主要方法:
- 一项纵向队列研究的二次分析,涉及110名患有NSCLC的参与者.
- 使用WHODAS 2.0子域评估移动性和参与性;通过POS-S测量症状负担.
- 在基线,2,4和6个月收集的数据;用重复测量ANOVA和回归模型分析.
主要成果:
- 移动性和症状负担保持稳定,参与度得分在4个月和6个月后有所改善 (p < 0.05).
- 运动能力的改善和下降都与参与度 (r=0.297-0.462) 和症状负担 (r=0.151-0.368) 的变化相关.
- 基线症状负担显著预测了流动性变化,即使在调整了人口统计和临床变量 (p=0.003) 之后.
结论:
- 尽管NSCLC患者的移动性稳定和症状负担较大,但在晚期NSCLC患者的参与度有所改善,这表明他们已经适应或从护理中受益.
- 流动性在功能上与症状负担和参与有关,作为有针对性的康复的关键指标.
- 晚期NSCLC的康复干预应将流动性视为功能性结果指标,受症状负担和参与水平的影响.
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