同时与反向混合疗法用于根除Helicobacter pylori感染 - 一个开放的随机对照试验
D K Ratul1, Sathasivam Sureshkumar1, Amaranathan Anandhi1
1Department of Surgery, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry 605 006, India.
新的非比斯木四倍 (并发) 和反向混合疗法在杆菌根除方面表现出类似的疗效. 这两种方案都提供了可比的合规性和不良事件概况,解决了不断增长的抗菌素耐药性挑战.
科学领域:
- 胃肠病学 胃肠病学
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 由于抗菌素耐药性,标准Helicobacter pylori根除方案的有效性下降.
- 作为替代治疗策略,非比斯木四重 (并发) 和反向混合疗法的出现.
- 需要比较这些新疗法的有效性和安全性.
研究的目的:
- 为了比较同步治疗 (CT) 与逆混合疗法 (RHT) 对H. pylori的根除疗效.
- 评估和比较患者对CT和RHT治疗方案的遵守情况.
- 评估和比较与CT和RHT相关的不良影响的发生率和类型.
主要方法:
- 前性,单中心,平行臂,开放标签,非劣势随机受控研究.
- 148 H. pylori 阳性胃潰瘍病和胃炎患者随机分为14天CT或RHT.
- 治疗后6周评估消除;遵守和不良事件被系统地记录下来.
主要成果:
- 根除率相似:CT的79.7%,而RHT的83.7% (ITT分析).
- 在两组中,合规性高且相似 (CT为91.4%,RHT为94.4%).
- 副作用的发生频率相似;味道变化是最常见的 (48.5%对42.9%).
结论:
- 14天的并发和反向混合疗法显示出可比的H. pylori根除疗效.
- 这两种疗法都表现出类似的患者合规率.
- 在这两种治疗策略之间,不良事件的总体发生率没有显著差异.
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