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Ke Ning¹, Dechao Fan², Yuzhu Liu³

¹Department of International Medical, Affiliated Zhongshan Hospital of Dalian University, No. 6 Jiefang Street, Dalian, 116001, China. ningke0801@163.com.

|December 19, 2025

概括

神经元导向分散和密度成像 (NODDI) 显示,在具有认知障碍的阻断性睡眠呼吸暂停下综合征 (OSAHS) 患者中,有可能诊断灰质变化. 这些微观结构变化与认知测试成绩相关.

科学领域:

神经成像是一种神经成像.
睡眠医学睡眠医学
认知神经科学认知神经科学

背景情况:

阻塞性睡眠呼吸暂停 (OSAHS) 与认知障碍有关.
在认知缺陷的OSAHS患者中,怀疑灰质微观结构的改变.

研究的目的:

通过NODDI.使用NODDI来调查OSAHS患者的灰质微观结构变化,包括有或没有认知障碍的患者.
评估NODDI参数对OSAHS认知障碍的早期诊断潜力.

主要方法:

在23名没有认知障碍的OSAHS患者 (OSA-NCI),43名认知障碍的OSAHS患者 (OSA-CI) 和15名健康的对照人群 (HC) 上使用神经元导向分散和密度成像 (NODDI).
在感兴趣的区域计算的分数异构性 (FA),神经质密度指数 (NDI),方向分散指数 (ODI) 和同位素水分子体积分数 (Viso).
与蒙特利尔认知评估 (MoCA) 和迷你精神状态检查 (MMSE) 分数相关的NODDI参数以及用于诊断评估的接收器操作特征 (ROC) 分析.

主要成果:

两组之间发现了NDI,ODI和Viso的显著差异;与HC相比,OSA-NCI显示NDI/ODI下降,Viso增加.
与HC相比,OSA-CI患者的Viso增加和NDI/ODI略有增加,但这些仍低于HC水平.
NDI,ODI和Viso与MoCA得分有显著的相关性,表明微结构完整性和认知功能之间存在联系;FA显示的相关性很弱.

结论:

NODDI参数,特别是Viso和ODI,显示出在OSAHS中检测与认知障碍相关的灰质病理的潜力.
这些发现表明NODDI作为OSAHS患者认知障碍的早期诊断工具的实用性.
建议在更大,独立的队列中进一步验证,以确认NODDI的诊断疗效.

关键词:

认知障碍认知障碍是一种认知障碍.灰色物质的微观结构神经质定向分散和密度成像 (NODDI)神经成像分析分析神经成像分析阻塞性睡眠呼吸暂停低呼吸综合征 (OSAHS)

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