激素替代疗法与绝经后妇女的耳部外科手术率降低有关
Naomi C Wang1,2, Jamie R Oliver1, Cole W VandeVelde1
1Department of Otolaryngology - Head and Neck Surgery, University of Kansas Medical Center.
概括
激素替代疗法 (HRT) 的使用显著降低了需要耳部外科手术的几率,在绝经后的女性中耳炎. 这表明,HRT对治疗耳部疾病的外科手术有潜在的保护作用.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 内分泌学 在内分泌学.
- 流行病学 流行病学
背景情况:
- 中耳炎是绝经后妇女常见的疾病.
- 对中耳炎的外科干预可能是侵入性的,并带有风险.
- 激素替代疗法 (HRT) 在耳部健康中的作用尚不清楚.
研究的目的:
- 调查HRT使用与被诊断患有中耳炎的绝经后妇女的耳科手术发生率之间的关联.
- 在HRT使用者中量化特定耳科手术的风险降低.
主要方法:
- 使用TriNetX全球协作网络进行的一项回顾性队列研究.
- 纳入标准:绝经后妇女 (≥55岁) 患有中耳炎,没有先前的耳部手术.
- 1:1倾向分数匹配创建了两个队列:HRT用户 (n=23,614) 和非用户 (n=23,614).
主要成果:
- 使用HRT与所有评估的耳科手术的几率显著降低有关.
- 耳部手术的综合发病率在HRT组为1.3%,而非HRT组为2.8% (OR:0.467,P <0.001).
- 特殊的手术,如 tympanostomy, myringotomy, tympanoplasty 和 mastoidectomy 也显示在HRT组显著降低了几率.
结论:
- 在患有中耳炎的绝经后妇女中,HRT的使用表明,在5年期间,接受耳部手术的几率减少了50% - 55%.
- 这项研究提供了新的证据,证明HRT在预防耳部疾病的外科手术中具有潜在的保护作用.
- 建议进行进一步的研究,以阐明这种观察到的关联的机制和临床影响.
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