酵素化小麦衍生酸盐通过协同调节肠道微生物群-肠道屏障轴来改善性结肠炎
Liansheng Zhang1, Mingfang Zhan2, Yan Zhao1
1Key Laboratory of Ministry of Education for Medicinal Resource and Natural Pharmaceutical Chemistry, College of Life Sciences, Shaanxi Normal University, Xi'an 710119, China.
Journal of agricultural and food chemistry
|December 19, 2025
概括
酵素化小麦衍生酸盐 (EEPZ) 显示了性结肠炎 (UC) 的治疗潜力. 在UC小鼠模型中,EEPZ改善了肠道微生物群,增强了肠道屏障功能,并调节了代谢概况.
科学领域:
- 胃肠道学和营养学
- 微生物组研究 微生物组研究
- 药理学 药理学是指药理学的学科.
背景情况:
- 性结肠炎 (UC) 是一种慢性炎症性肠病,治疗选择有限.
- 麦花酸盐以其潜在的健康益处而闻名,但其生物可用性和UC中的治疗机制需要进一步研究.
- 酶性水解可能会提高酸盐的生物可用性和治疗疗效.
研究的目的:
- 在硫酸 (DSS) 诱导的UC小鼠模型中评估酶化化小麦衍生酸盐 (EEPZ) 的治疗潜力.
- 为了比较EEPZ与化学合成的酸盐 (ZnPA) 和全麦 (WHB).
- 阐明EEPZ对肠道微生物群,新陈代谢和肠道屏障功能的治疗作用的潜在机制.
主要方法:
- 在小鼠中使用DSS诱导UC.
- 给UC小鼠使用EEPZ,ZnPA或WHB.
- 使用16S rRNA测序对肠道微生物群组成的分析.
- 短链脂肪酸和胆酸的代谢分析.
- 对肠道屏障完整性标记物 (HDAC3,ZO-1,ocludin) 和信号通路 (PI3K/AKT/NF-κB) 的评估.
主要成果:
- EEPZ显著调节了肠道微生物群,增加了有益的*Lactobacillus vaginalis*并减少了有害的*Desulfovibrio*.
- *Lactobacillus vaginalis*将EEPZ转化为可生物利用的内醇酸盐和离子.
- EEPZ改变了短链脂肪酸和胆汁酸的形状,特别是增加了陈二氧化醇酸和胆汁酸.
- 通过对HDAC3和紧密结合蛋白 (ZO-1,ocludin) 的上调,EEPZ加强了肠道屏障的完整性.
- EEPZ抑制了促炎性PI3K/AKT/NF-κB信号通路.
结论:
- 酵素化小麦衍生酸盐 (EEPZ) 显示出对性结肠炎的显著治疗潜力.
- 通过调节肠道微生物群,增强肠道屏障功能和调节宿主代谢通路来发挥EEPZ的作用.
- EEPZ代表了一个有前途的新型,自然治疗候选人UC管理.
相关概念视频
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
614
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
614
Pathophysiology of Peptic Ulcer Disease: Mucosal Defense Factors
1.1K
Peptic ulcer disease, commonly called PUD, represents a multifaceted condition characterized by disruptions in the lining of the gastrointestinal (GI) tract. Central to the protection of the gastrointestinal lining is the mucosal-bicarbonate barrier. This physiological defense mechanism is a formidable shield against the corrosive effects of gastric acid and pepsin secretion in the stomach. Its role is pivotal in maintaining the structural integrity of the stomach's inner lining.
1.1K
Peptic Ulcer Disease I: Introduction
711
Peptic Ulcer Disease (PUD) is characterized by mucosal excavation in the esophagus, stomach, pylorus, or duodenum. It can manifest as acute or chronic based on the extent and duration of mucosal involvement.
An acute ulcer, marked by superficial erosion and minimal inflammation, swiftly resolves upon identifying and addressing the underlying cause. In contrast, a chronic ulcer persists, potentially eroding through the muscular wall and forming fibrous tissue.
Peptic ulcers can also be...
An acute ulcer, marked by superficial erosion and minimal inflammation, swiftly resolves upon identifying and addressing the underlying cause. In contrast, a chronic ulcer persists, potentially eroding through the muscular wall and forming fibrous tissue.
Peptic ulcers can also be...
711
Drugs for Treatment of Ulcerative Colitis in IBD
424
Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...
424
Peptic Ulcer Disease IV: Management
401
Medical treatment strategies for peptic ulcers encompass various methods. The primary goal of treatment is to diminish gastric acidity and strengthen mucosal defense mechanisms.
The therapeutic approach involves ensuring adequate rest, implementing drug therapy, promoting smoking cessation, making dietary modifications, and emphasizing long-term follow-up care.
Pharmacological management
The prevailing therapy for peptic ulcers involves a combination of managing the patient's current...
The therapeutic approach involves ensuring adequate rest, implementing drug therapy, promoting smoking cessation, making dietary modifications, and emphasizing long-term follow-up care.
Pharmacological management
The prevailing therapy for peptic ulcers involves a combination of managing the patient's current...
401
Pathophysiology of Peptic Ulcer Disease: Injurious Factors
1.1K
Peptic ulcers are sores on the stomach's inner lining and the upper small intestine, which are the result of disruptions in the mucosal layer that houses parietal cells which produce gastric acid, and chief cells which secrete pepsinogen.
In the antrum region, G cells secrete the gastrin hormone that binds to gastrin-cholecystokinin-B (CCK2) receptors on parietal and enterochromaffin-like (ECL) cells in the fundic glands. Simultaneously, the vagus nerve releases acetylcholine, which binds...
In the antrum region, G cells secrete the gastrin hormone that binds to gastrin-cholecystokinin-B (CCK2) receptors on parietal and enterochromaffin-like (ECL) cells in the fundic glands. Simultaneously, the vagus nerve releases acetylcholine, which binds...
1.1K


