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Updated: Jun 10, 2026

An Air-liquid Interface Bronchial Epithelial Model for Realistic, Repeated Inhalation Exposure to Airborne Particles for Toxicity Testing
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聚烯纳米塑料在人类肺上皮细胞BEAS-2B和HaCaT细胞中的表面电荷依赖毒性

So Young Kyung1, Seung Jun Kwack2, Byung Mu Lee1

  • 1School of Pharmacy, Sungkyunkwan University, Suwon, Republic of Korea.

Journal of toxicology and environmental health. Part A
|December 19, 2025
PubMed
概括

负电荷纳米塑料 (NP) 对肺和皮肤细胞的毒性比负电荷纳米塑料更高. 这种细胞损伤与氧化应激增加有关,突出显示表面电荷是NP健康风险的关键因素.

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Toxicity Testing in Animals01:23

Toxicity Testing in Animals

Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...