青春期前男性的青春期诱导与性性性性:或淋巴激素?
Paolo Cavarzere1, Riccardo Battiston2, Valentina Lupieri2
1Department of Mother and Child, Pediatric Clinic B, University Hospital of Verona, Verona, Italy.
Clinical and experimental pediatrics
|December 19, 2025
概括
在男性中诱导青春期 具有性性性性 (HH) 是具有挑战性的. 丸激素和淋巴激素疗法都有效,但对男性化和生育能力的最佳方案需要进一步研究.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 生殖医学 生殖医学
- 临床治疗学 临床治疗学
背景情况:
- 患有低阴性腺症 (HH) 的男性的青春期诱导存在重大临床挑战.
- 目前的治疗策略涉及丸激素或淋巴激素缺乏标准化的最佳协议来启动和维持青春期.
- 了解不同治疗方法的疗效和长期结果对于患者管理至关重要.
研究的目的:
- 审查和分析治疗方案的青春期诱导在男性的HH.
- 评估基于和淋巴激素的疗法的疗效和结果.
- 识别当前治疗方案中的差距,并建议未来研究的方向.
主要方法:
- 在2004年1月至2024年7月期间发表的研究在2024年7月进行了全面的PubMed搜索.
- 使用的关键词包括"在男性中诱导青春期".
- 纳入标准侧重于18岁以下患有HH的男性患者的英语研究;动物研究,成人队列和非HH组被排除在外. 18项研究符合标准.
主要成果:
- 丸激素和淋巴激素疗法都有效地诱导了患有HH的男性的青春期.
- 肌肉内丸激素因可获得性和成本而普遍存在,而通过皮肤的配方提供更好的耐受性.
- 淋巴激素疗法 (单独使用hCG或与FSH一起使用) 促进了病毒化,丸生长和精子生成,这表明潜在的生育益处.
结论:
- 虽然丸激素有助于男性化,但淋巴激素可以增强丸的发育和精子生成,这对未来的生育能力至关重要.
- 在配方,剂量,持续时间和服用途径方面存在显著的异质性,这突显了缺乏标准化指导方针.
- 需要进行更多的多中心研究,以建立最佳的治疗方案,并澄清不同治疗策略的长期生育结果,以诱导HH的青春期.
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