低小腿周长与住院心力衰竭患者的高血N-终端亲B型自然尿素相关:一项回顾性研究
Jacob Jonatan Cruz-Sánchez1,2, Francisco Javier González-Ruiz3, Carla Gabriela Aguilar-Rodríguez1
1Division of Surgical and Medical Specialties, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico.
概括
低肌肉质量,以小腿周长为标志,在心力衰竭患者中很常见,并且与较高的心脏压力标志物有关. 这表明小牛周长可以改善心力衰竭的营养不良查.
科学领域:
- 心脏病学 心脏病学
- 营养科学 营养科学
- 老年病的医生 老年病的医生
背景情况:
- 心力衰竭 (HF) 影响全球数以百万计的人,常常因营养不良和肉症而复杂化.
- 低肌肉质量 (MM) 是一个关键特征,可以通过身体质量指数 (BMI) 调整的小腿周长 (CC) 来衡量.
- 尽管全球营养不良领导倡议提出了建议,但CC并不是营养查的标准,尽管低MM与高频率的N-终端亲B型性尿素 (NT-proBNP) 相关.
研究的目的:
- 研究住院心力衰竭患者的BMI调整后的CC和NT-proBNP水平之间的关联.
- 确定CC是否可以作为HF营养不良的实际指标.
主要方法:
- 一项对202名住院HF患者进行的回顾性横截面研究.
- 收集的数据包括人口统计,人体测量 (包括BMI调整的CC) 和生化标志物.
- 使用斯皮尔曼相关性和多变量线性回归分析了BMI调整后的CC和NT-proBNP之间的关联.
主要成果:
- 在HF患者中观察到低BMI调整的CC (74.8%) 的高患病率.
- 与正常CC患者 (5621 pg/ml) 相比,低CC患者的NT-proBNP水平显著更高 (11,970 pg/ml).
- 经BMI调整后的CC显示,在对混因子进行调整后,与NT-proBNP度有显著的反向关联 (β = -927).
结论:
- 低肌肉质量在心力衰竭患者中非常普遍.
- 低BMI调整CC与高NT-proBNP有关,这表明肌肉耗尽和心脏压力之间存在联系.
- 将BMI调整的CC纳入营养评估可能会提高HF患者的营养不良识别和风险分层.
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