在超脂性急性胰腺炎中,炎症指数和甘油三的诊断价值
Tao Liu1, Shufang Ye1, Ke Wang1
1Department of Gastroenterology, Lishui Hospital of Wenzhou Medical University, The First Affiliated Hospital of Lishui University, Lishui People's Hospital Lishui 323000, Zhejiang, China.
American journal of translational research
|December 19, 2025
概括
血小板与淋巴细胞比率 (PLR) 和全身炎症反应指数 (SIRI) 有效地诊断高脂性急性胰腺炎 (HLAP). 将这些炎症标志物与甘油三水平 (TG) 结合起来,为早期的HLAP识别提供了一个强大的方法.
科学领域:
- 生物化学和临床诊断学
- 胃肠病学和肝病学
背景情况:
- 过高的甘油三 (TG) 水平在急性胰腺炎 (AP) 中构成诊断挑战.
- 早期发现超脂性急性胰腺炎 (HLAP) 对于及时干预至关重要.
研究的目的:
- 评估炎症指数的诊断效用,特别是血小板与淋巴细胞比率 (PLR) 和全身炎症反应指数 (SIRI),用于识别HLAP.
- 评估PLR,SIRI和TG水平在HLAP诊断中的联合诊断性能.
主要方法:
- 140名AP患者的回顾性队列研究,包括59例HLAP病例.
- 与健康对照组和高甘油三血症 (HTG) 个体进行比较.
- 对炎症指数 (PLR,SIRI,NLR,MLR,SII) 的计算和ROC分析;开发和外部验证综合诊断模型 (PLR+SIRI+TG).
主要成果:
- 与非HLAP,HTG和健康对照相比,HLAP患者的PLR和SIRI显著升高.
- SIRI显示了最高的诊断疗效 (AUC=0.973),其次是PLR (AUC=0.960).
- 组合模型 (PLR+SIRI+TG) 实现了卓越的诊断性能 (AUC=0.988),得到了外部验证.
结论:
- PLR和SIRI是早期HLAP诊断的有价值,可访问的生物标志物.
- PLR,SIRI和TG的组合模型提供了一种可靠的方法,用于快速识别和管理HLAP.
相关概念视频
01:30Acute Pancreatitis II: Clinical Manifestations and Management
702
Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
702
01:27Acute Pancreatitis I: Introduction
1.1K
Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
1.1K
01:24Chronic Pancreatitis I: Introduction
645
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
645
01:29Chronic Pancreatitis II: Collaborative Care
286
The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
Assessment:
286
01:25Blood Studies for Cardiovascular System III: Serum Lipid Profile
534
Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
534
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
518
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
518