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TNXB通过ATM/P53通路调节食道癌的辐射敏感性

Huiying Yang¹, Ning Xu¹, Xiaoling Cao¹

¹Department of Gastroenterology, Binzhou Medical College Yantai Affiliated Hospital Yantai 264100, Shandong, China.

American journal of translational research

|December 19, 2025

概括

素XB (TNXB) 的过度表达通过通过ATM/P53通路促进DNA损伤和亡来增强食道癌细胞 (ESCA) 的放射敏感性,为癌症治疗提供了潜在的标.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
辐射疗法辐射疗法

背景情况:

食道癌 (ESCA) 是一种普遍存在的恶性瘤.
调节瘤的辐射敏感性是有效的,个性化的癌症治疗的关键.
素XB (TNXB) 是一种蛋白质,其在ESCA辐射敏感性中的作用需要研究.

研究的目的:

在实验室中研究特纳辛XB (TNXB) 过度表达对人类食道癌 (ESCA) 细胞辐射敏感性的作用.
探索潜在的分子机制,包括DNA损伤,细胞亡和细胞循环调节.

主要方法:

实时定量聚合酶连锁反应 (RT-qPCR) 和免疫组织化学被用来评估瘤组织中的TNXB表达.
人类ESCA细胞系 (TE-1和OE33) 用于评估TNXB对辐射敏感性的影响.
殖民地形成试验,西部涂抹和流动细胞测量被用来测量DNA损伤,细胞亡和细胞循环停止.

主要成果:

发现TNXB的表达在瘤组织中很低,并且与不良的临床病理特征相关.
与X射线照射相结合的TNXB过度表达显著抑制了ESCA细胞中的殖民地形成和增加了细胞亡和细胞循环停止.
组合治疗提高了ATM和P53酸化的调节,导致分裂酶3的增加,这种效应被si-ATM治疗逆转.

结论:

素XB (TNXB) 的过度表达显著提高了食道癌 (ESCA) 细胞的放射敏感性.
这种辐射敏感化效应是通过ATM/P53信号通路的激活来实现的.
在ESCA治疗中,TNXB代表了改善放射敏感性的潜在治疗标.

关键词:

这是一个ATMATMATM.在P53中,P53是P53 在TNXBB上.食管状细胞癌的癌症辐射敏感性辐射敏感性

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