激素与甲状腺功能异常的相关性及其在乳腺癌中的辅助诊断价值
1Department of Traditional Chinese Medicine, The First Affiliated Hospital of Xi'an Jiaotong University Xi'an 710061, Shaanxi, China.
American journal of translational research
|December 19, 2025
概括
甲状腺激素自由甲状腺素 (FT4) 和甲状腺过氧化酶抗体 (TPO-Ab) 与乳腺癌的发生和进展有关. 高水平的FT4和TPO-Ab可以预测乳腺癌的风险和复发.
科学领域:
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
- 生物标志物发现发现
背景情况:
- 甲状腺激素在细胞代谢和生长中起着至关重要的作用.
- 甲状腺功能的改变已与各种癌症有关,但它们在乳腺癌中的特定作用需要进一步阐明.
研究的目的:
- 研究乳腺癌患者血清甲状腺激素水平与病理特征之间的关联.
- 评估甲状腺激素在乳腺癌中的诊断和预测价值.
主要方法:
- 对120名乳腺癌患者和100名健康对照者的回顾性分析.
- 测量血清中的自由三甲状腺素 (FT3),自由甲状腺素 (FT4),甲状腺刺激激素 (TSH),甲状腺蛋白抗体 (TG-Ab) 和甲状腺过氧化酶抗体 (TPO-Ab).
- 接收器操作特征 (ROC) 曲线分析和与病理特征的相关性分析.
主要成果:
- 与对照组相比,乳腺癌患者的血清FT4和TPO-Ab水平显著更高,尽管在正常范围内.
- ROC分析表明FT4 (AUC=0.701) 和TPO-Ab (AUC=0.805) 的诊断性能良好.
- FT4和TPO-Ab水平与瘤大小,临床阶段,淋巴结转移和激素受体状态 (ER/PR) 有显著的关联.
结论:
- 血清FT4和TPO-Ab水平与乳腺癌的发生,进展和病理特征密切相关.
- 这些与甲状腺相关的标记物对乳腺癌具有诊断和预测价值.
- FT4和TPO-Ab可以作为评估乳腺癌复发风险的潜在生物标志物.
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