环境化学物质作为年龄和卵巢储备之间的关联的修饰者
Ashley I Naimi1, Edward H Kennedy2, Ya-Hui Yu1
1Department of Epidemiology, Emory University.
medRxiv : the preprint server for health sciences
|December 19, 2025
概括
对某些酸盐的更高暴露,如MiBP和MCOP,加快了与年龄相关的卵巢储备下降 (腹腔毛囊数量). 这表明,酸盐可能会加速女性的生殖衰老.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
背景情况:
- 前毛囊数量 (AFC) 随着年龄的增长自然下降,反映出卵巢储备的减少.
- 内分泌干扰化学物质 (EDC) 是可以干扰荷尔蒙系统的环境剂.
- EDCs对与年龄相关的AFC衰退的影响尚未完全理解.
研究的目的:
- 调查EDC的较高度是否会加剧与年龄相关的AFC减少.
- 为了确定特定的EDC,修改年龄和AFC之间的关联.
主要方法:
- 研究人员对775名21至46岁的女性进行了前性队列研究.
- 用机器学习方法双强学习 (DR) 学习器来建模暴露-结果关系.
- 评估了16种EDC (甲酸盐代谢产物, parabens, BPA) 和头发的尿度作为年龄-AFC关联的潜在修饰因素.
主要成果:
- 三种EDC显著改变了年龄-AFC关系.
- 尿液中单异布甲酸盐 (MiBP) 和单氧甲酸盐 (MCOP) 的较高度与AFC随着年龄的增长而急剧下降有关.
- 较高的头发 (Hg) 度与年龄和AFC之间的负相关性较弱有关.
结论:
- 特定的甲酸盐代谢物 (MiBP,MCOP,MEHP) 与与年龄相关的卵巢储备的加速下降有关.
- 这些发现表明,某些酸盐可能会加速女性的生殖衰老.
- 剂量依赖关系表明女性生育的潜在环境风险.
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