试图治愈而不"带来问题":在肯尼亚西部的一阶段临床试验中,在子宫癌前期的污名化中进行导航
Anagha Guliam1, Annum Sadana2,3, Elizabeth Opiyo4
1Columbia University Vagelos College of Physicians and Surgeons, New York, New York, United States.
medRxiv : the preprint server for health sciences
|December 19, 2025
概括
社会文化污名严重影响妇女的宫癌前期护理,影响她们的决策和自我治疗治疗的经验. 解决这些耻辱是改善治疗坚持和结果在低资源环境中至关重要的.
科学领域:
- 全球健康 全球健康
- 妇女健康 妇女健康
- 医学社会学 医学社会学
背景情况:
- 宫癌是低收入和中等收入国家的妇女死亡的主要原因,特别是在撒哈拉以南非洲.
- 社会文化因素,包括耻辱感,深刻影响妇女参与宫癌查和治疗.
研究的目的:
- 调查耻辱对妇女在宫癌前期护理方面的经验的影响.
- 探索这些经验在新的自我管理局部治疗的背景下.
主要方法:
- 一个使用方便抽样的定性研究.
- 在肯尼亚基苏穆 (Kisumu) 进行了17次深入采访,这些女性被诊断患有子宫癌前期,参与了阴道内阿尔特苏纳特的I期临床试验.
- 使用健康污名和歧视框架进行了主题分析.
主要成果:
- 妇女报告说,与伴侣指责,披露和死亡恐惧有关的行为,预期和内化耻辱.
- 耻辱的驱动因素包括贫困,有限的医疗保健,尬,社区的恐惧,父权主义的规范,以及子宫癌前期的负担.
- 妇女通过关系自主,完成治疗和启动社区对话来摆脱耻辱,尽管有些人面临延迟,亲密伴侣暴力或冲突.
结论:
- 与子宫癌前期,使用甲酸盐和禁欲要求相关的耻辱感会对女性的社交生活,关系和心理健康产生负面影响.
- 未来的自我治疗疗法的试验必须包含与参与者和幸存者共同开发的耻辱化减少策略.
- 临床试验.gov 标识符:NCT06165614.
更多相关视频
03:07Single-Port Robotic-assisted Transaxillary Breast-conserving Surgery: A Prospective, Single-arm, Non-randomized Phase IIa Clinical Trial
Published on: August 19, 2025
766
05:52Sentinel Lymph Node Mapping and Biopsy for Endometrial Cancer at Early Stage with Laparoscopy
Published on: August 19, 2021
12.9K
相关概念视频
Cancer Prevention
7.6K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
7.6K
Clinical Trials: Overview
4.5K
Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
4.5K
Clinical Trials
10.1K
Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
There are four phases in a clinical trial. A phase one...
10.1K
Cancer
53.4K
Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
53.4K
Cancer Survival Analysis
629
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
629
Treatment Resistant Cancers
3.7K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.7K
