牛脂肪线粒体适应和早期哺乳期潜在的乳酸-基切换
Nial J O'Boyle1, Miguel Chirivi2, Ursula Abou-Rjeileh2
1School of Veterinary Medicine and Science, University of Nottingham, Nottingham, United Kingdom.
Frontiers in veterinary science
|December 19, 2025
概括
在早期哺乳期,奶牛从氧化酸化转变为脂肪组织中的糖解,可能会影响代谢疾病. 可以作为适应信号,而不仅仅是疾病标志物.
科学领域:
- 奶牛的新陈代谢 奶牛的新陈代谢
- 动物生理学 动物生理学
- 分子生物学分子生物学
背景情况:
- 周周期对哺乳母牛的能量需求很高,增加了代谢障碍的风险.
- 皮下脂肪组织 (AT) 在能量恒温中起着至关重要的作用,但其产后适应性尚未完全理解.
- 线粒体是通过氧化酸化 (OXPHOS) 进行细胞能量生产的核心,但它们在分娩后代谢健康中的作用尚不清楚.
研究的目的:
- 调查乳牛在过渡到哺乳期期间皮下AT的转录组适应性.
- 专门研究线粒体通路和代谢基因网络在产后适应中的作用.
- 探索改变的代谢状态,血乳酸和体之间的关系.
主要方法:
- 重新分析了从荷尔斯坦牛的纵向RNA-seq数据集,这些牛在分娩前和早期哺乳期取样.
- 差异基因表达分析专注于代谢和线粒体基因.
- 与代谢状态相关的血乳酸盐和β-基酸盐水平的分析.
主要成果:
- 在产后观察到参与电子运输和OXPHOS的基因的降低调节,同时在AT中转向高调 glycolytic 基因.
- 血乳酸水平在分娩后下降,而β-基酸盐在性奶牛中增加,这表明代谢切换.
- 确定了乳酸盐和体之间的潜在代谢相互作用,受氧化还原和代谢条件的影响.
结论:
- 乳牛在早期哺乳期在脂肪组织中表现出显著的转录基因转移,从OXPHOS向糖解转移.
- 体可以作为适应性代谢信号而不是仅仅是产后奶牛的病理指标.
- 了解线粒体功能和脂肪组织适应对于改善早期哺乳期奶牛的代谢弹性至关重要.
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