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微流体肺癌模型:结合临床治疗策略和瘤微环境复习

Zhiyun Yu¹, Arsalan A Khan¹, Wara Naeem¹

¹Department of Cardiovascular and Thoracic Surgery, Rush University Medical Center, 1725 W Harrison Street, Chicago, Illinois 60612, USA.

APL bioengineering

|December 19, 2025

概括

肺癌研究面临着传统模型的挑战. 微流体肺上芯片技术为改善肺癌建模和药物开发提供了一个3D,生理相关的平台.

科学领域:

生物医学工程生物医学工程
在瘤学瘤学.
翻译医学是一种翻译医学.

背景情况:

肺癌是导致死亡的主要原因,非小细胞肺癌是最常见的亚型.
目前的临床前模型难以复制肺部的复杂性,阻碍了有效的药物开发.
器官芯片技术为克服这些局限性提供了一种新的方法.

研究的目的:

审查用于肺生理和癌症建模的微流体系统的进展.
探索这些模型在疾病理解和药物测试中的应用.
弥合生物工程与肺癌研究中的临床实践之间的差距.

主要方法:

对微流体平台进行审查,以回顾肺部结构和微环境.
在3D模型中整合人体细胞, perfusion 和机械线索.
纳入临床医生对当前肺癌治疗和模型实用性的见解.

主要成果:

微流体肺上芯片模型在复制肺癌生物学和药物反应方面提供了更高的准确性.
这些平台有助于研究瘤异质性和抵抗机制.
这项技术对个性化瘤学和改进药物开发充满希望.

结论:

微流体肺上芯片技术代表了对肺癌研究传统模型的重大进步.
跨学科的合作,特别是与临床医生合作,对于将这些系统转化为临床实践至关重要.
这些模型具有个性化癌症治疗和增强药物疗效预测的翻译潜力.

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