儿童模型信息精准治疗的成年期
1Cincinnati Children's Hospital Medical Center & University of Cincinnati, College of Medicine, Cincinnati, OH.
概括
针对儿童的精确剂量正在成为现实,超越理论进入临床实践. 基于模型的精确剂量 (MIPD) 显示了改善儿科治疗结果的前景.
科学领域:
- 儿科药理学 儿科药理学
- 临床决策支持 临床决策支持
- 精准医学是一门精准的医学.
背景情况:
- 药物开发过程通常针对普通患者,与精准医学目标形成悖论.
- 儿科临床药理学已经发展,面临儿童剂量优化方面的挑战.
研究的目的:
- 审查精准医学在儿科药物治疗中的进展.
- 突出模型信息精确剂量 (MIPD) 在临床实践中的整合.
- 提供使用MIPD的儿童治疗结果改善的证据.
主要方法:
- 对儿科临床药理学史的回顾.
- 讨论儿科药物开发和精准医学方面的挑战.
- 关于实施基于模型的临床决策支持工具的案例研究的介绍.
- 电子健康记录集成MIPD的例子.
主要成果:
- 儿科精确剂量正在从概念过渡到临床工作流程实施.
- 已经成功地将MIPD工具集成到电子健康记录中.
- 基于模型的治疗药物管理对于儿科患者来说在临床上是可行的.
结论:
- 基于模型的精确剂量 (MIPD) 是优化儿科药物治疗的可行方法.
- 与标准护理相比,MIPD工具的实施可以改善儿童的临床结果.
- 将MIPD集成到临床工作流中,代表了儿科精密医学的重大进步.
关键词:
在此之前,Eculizumab也曾被使用过.基尿素的含量是多少这就是Infliximab的价值.梅尔法兰 (Melphalan) 是一个有趣的词.甲基特雷克萨酸盐的使用方法基于模型的精确剂量 (MIPD)这是吗啡吗啡.这是西洛利斯 ( sirolimus).更多相关视频
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