沃克斯综合征:报告病例的系统审查
Badrun Shurovi1, Benjamin Samra2
1Otolaryngology, Royal London Hospital, London, GBR.
Cureus
|December 19, 2025
概括
沃克斯综合征是一种罕见的CRSwNP,导致鼻子形,需要进行激进的手术和长时间的类固醇治疗. 长期控制是具有挑战性的,但新的疗法可能有助于严重的病例.
科学领域:
- 鼻科和耳鼻喉科 鼻科和耳鼻喉科
- 炎症性气道疾病 炎症性气道疾病
- 系统性审查和元分析
背景情况:
- 沃克斯综合征是一种罕见的,具有鼻息肉性慢性鼻炎 (CRSwNP) 的侵袭性形式.
- 它的特点是鼻腔框架的逐渐扩张,导致面部形.
- 了解其临床特征和管理对于患者的治疗结果至关重要.
研究的目的:
- 系统地审查有关沃克斯综合征的文献.
- 描述其临床特征,并发症,管理和结果.
- 为了确定这一罕见疾病的挑战和潜在的未来治疗方法.
主要方法:
- 在主要数据库 (PubMed,Embase,Cochrane图书馆) 中按照PRISMA指南进行系统的文献搜索.
- 包括所有报告Woakes综合征临床数据的研究类型.
- 提取的关于人口统计,并发病,治疗和结果的数据的描述性综合.
主要成果:
- 分析了23项涉及39名患者的研究 (平均年龄为39.5岁,65%是男性).
- 常见的并发病包括萨姆特的三位一体和鼻肺部疾病.
- 所有患者都接受了手术 (FESS,鼻美术),通常使用类固醇;有7例复发病例,其中6例尽管使用鼻类固醇.
结论:
- 沃克斯综合征是一种独特的,侵略性的CRSwNP表型,导致面部形,影响儿童和成人.
- 管理包括积极的手术和长期的类固醇治疗,但长期控制仍然很困难.
- 新兴的生物疗法可能为耐火病例提供未来的好处.
相关概念视频
01:21Aneurysm II: Clinical Manifestations and Diagnostic Studies
176
Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
176
01:22Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies
435
The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
435
01:21Barrett Esophagus-II: Clinical Manifestations and Management
726
Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
726
01:30Acute Coronary Syndrome III: Diagnostic Studies
190
Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
190
01:13Seizures: Classification
1.3K
Epilepsy is primarily characterized by unpredictable seizures, either provoked by an identifiable factor, such as injury or illness, or unprovoked, occurring spontaneously without apparent cause.
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
1.3K
01:20Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies
262
The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
262