运动反应性circTSN作为COPD康复期间潜在的系统生物标志物
Lei Zhao1, Fan Bai2, Haizhu Zeng1
1Department of Pulmonary and Critical Care Medicine, Shanghai Pudong New Area Gongli Hospital, Shanghai, China.
Frontiers in medicine
|December 19, 2025
概括
在慢性阻塞性肺病 (COPD) 中,运动可调节circTSN,作为miR-144-3p的分子海绵. 这种circTSN-miR-144-3p轴对于COPD中运动诱导的肺适应至关重要.
科学领域:
- 分子生物学分子生物学
- 肺部病理学 肺部病理学
- 遗传学 遗传学 是一个
背景情况:
- 慢性阻塞性肺病 (COPD) 涉及全身和肺部问题.
- 运动可以改善COPD,但潜在的分子机制尚不清楚.
- 非编码RNAs在COPD运动适应中的作用基本上是未知的.
研究的目的:
- 确定循环RNAs (circRNAs) 在COPD中调解炼适应.
- 在这个过程中,研究circTSN (hsa-circ_0003789) 作为一个关键的circRNA.
主要方法:
- 在COPD患者中使用外周血液RNA测序的前性队列研究.
- RT-qPCR验证,COPD小鼠模型,双露西法酶记者测定和体外细胞实验.
- 研究了circTSN作为miR-144-3p竞争的内源RNA (ceRNA) 的机制.
主要成果:
- 在COPD患者和小鼠模型中,circTSN表达在运动后增加,独立于其宿主基因.
- 在气道上皮细胞中,circTSN充当miR-144-3p的分子海绵.
- 环TSN-miR-144-3p轴调节炎症基因,对运动介导的肺适应至关重要.
结论:
- 在COPD中,circTSN作为一个分子传感器,将肺部变化与运动期间的全身适应联系起来.
- 这一发现提供了对COPD运动益处的机制性见解.
- circTSN是COPD监测和治疗策略的潜在目标.
关键词:
交通运输系统网络 (Translin)心肺运动测试 (CPET) 是指心肺运动测试.慢性阻塞性肺病 慢性阻塞性肺病环绕 TSN 的 TSN.运动训练 运动训练 运动训练这是一种炎症炎症炎症炎症.平均响应时间 (MRT)肺部康复 (PR) 肺部康复更多相关视频
相关概念视频
01:27Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies
3.1K
Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
Medical History
3.1K
01:22Chronic Obstructive Pulmonary Disease
2.2K
COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
2.2K
01:26COPD: Management Using Bronchodilators and Corticosteroids
692
Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
692
01:20Chronic Obstructive Pulmonary Disease-I: Introduction
3.5K
Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.
3.5K
01:20COPD: Pathogenesis and Clinical Features
1.7K
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
1.7K
01:20Chronic Obstructive Pulmonary Disease-II: Pathophysiology
4.1K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Chronic Inflammation
4.1K