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在急性心肌梗塞和其治疗潜力的巨极化动态调节

Anchen Xu^1,2, Shuai Xu^1,2, Xin Tan^1,2

¹Department of Cardiology, The Fourth Affiliated Hospital of Soochow University, Suzhou Dushu Lake Hospital, Medical Center of Soochow University, Suzhou, 215000, People's Republic of China.

Journal of inflammation research

|December 19, 2025

概括

巨细胞是急性心肌梗塞 (AMI) 的关键免疫细胞. 从M1 (炎症) 转移到M2 (修复) 的巨细胞极化是改善心脏病发作结果的有希望的治疗标.

科学领域:

心血管免疫学心血管免疫学
炎症和免疫的作用
心肌梗塞研究研究的心肌梗塞.

背景情况:

急性心肌梗塞 (AMI) 涉及复杂的免疫反应,其中巨细胞起着关键作用.
巨细胞两极分化 (M1与M2) 决定了它们在心肌损伤和修复中的功能.
M1巨细胞促进炎症,而M2巨细胞则有助于AMI后的组织修复和重塑.

研究的目的:

审查AMI期间巨细胞两极分化的动态变化.
详细阐述M1和M2巨细胞在心肌损伤,炎症和修复中的作用.
突出针对巨细胞两极分化的治疗策略,以改善AMI结果.

主要方法:

文献综述总结了AMI中巨细胞极化动态.
分析M1和M2巨细胞在心脏损伤和愈合中的作用.
概述新兴的治疗方法,包括药理学药物和基因编辑.

主要成果:

在AMI期间,巨细胞两极分化会动态变化,影响损伤和修复过程.
M1极化有助于最初的炎症和死组织清除.
M2极化对于组织修复的后期阶段至关重要,减少纤维化和促进重塑.

结论:

调节巨细胞两极分化,特别是促进M1到M2的过渡,是AMI的关键治疗策略.
向巨细胞功能为增强心肌修复和预防心脏不良事件提供了新的见解.
新兴的疗法,如mTOR抑制剂,SGLT2抑制剂,GLP-1受体激动剂和CRISPR/Cas9,在调节AMI治疗的巨细胞极化方面显示出潜力.

关键词:

在M1/M2巨细胞中.剧烈的心肌梗塞急性心肌梗塞巨细胞的两极分化基于巨细胞的治疗策略心肌重塑是指心肌的重塑.

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