[多种生活方式因素对心血管生物衰老的影响及其相对贡献]
Jiajie Cai1, Ning Zhang1, Yi Xiang1
1/ ( 610041) Department of Epidemiology and Biostatistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu 610041, China.
概括
健康的生活方式选择显著减缓心血管生物衰老. 饮食和酒精消费是关键因素,饮食对女性和酒精对男性特别有影响,建议针对性干预.
科学领域:
- 心血管健康的心血管健康
- 衰老的研究研究.
- 生活方式医学生活方式医学
背景情况:
- 心血管生物衰老 (CBA) 是心血管健康的关键指标.
- 了解影响CBA的可修改的生活方式因素对于预防策略至关重要.
研究的目的:
- 调查健康生活方式因素与CBA之间的关联.
- 确定不同生活方式因素对CBA加速的相对贡献.
主要方法:
- 利用英国生物库数据 (n=251,478) 用Klemera-Doubal方法 (KDM) 计算CBA和CBA加速.
- 使用多重线性回归和量子g计算 (QGC) 来分析生活方式因素的关联和贡献.
- 根据性别,BMI,种族和心血管疾病史进行了分层分析.
主要成果:
- 健康的生活方式得分与CBA加速 (β = -0.75) 有负相关性.
- 酒精消费 (25.8%) 和饮食 (25.7%) 是CBA加速的最大贡献者.
- 观察到的性别差异:女性饮食影响最大 (34.5%),男性饮酒 (29.5%).
结论:
- 可修改的生活方式因素可以有效地减缓心血管生物衰老.
- 饮食和酒精消费是减少CBA加速的干预措施的重要目标.
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